{"id":"W3112742288","doi":"10.1080/15412555.2020.1853091","title":"Lung Deposition Using the Respimat<sup>®</sup> Soft Mist™ Inhaler Mono and Fixed-Dose Combination Therapies: An <i>In Vitro</i>/<i>In Silico</i> Analysis","year":2020,"lang":"en","type":"article","venue":"COPD Journal of Chronic Obstructive Pulmonary Disease","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Boehringer Ingelheim","keywords":"Inhaler; In silico; COPD; Pulmonary disease; In vitro; Mist; Deposition (geology); Lung; Medicine; Dry-powder inhaler; Materials science; Chemistry; Biology; Internal medicine; Asthma; Physics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000372698,0.0002403481,0.0005021082,0.0004114978,0.0001541208,0.00005801849,0.0001571918,0.0000986987,0.00006364507],"category_scores_gemma":[0.0001237907,0.0001844366,0.0002422112,0.0008355132,0.0001962686,0.000617639,0.00004555763,0.000494685,0.000001674782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004880923,"about_ca_system_score_gemma":0.0004950931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001576105,"about_ca_topic_score_gemma":0.000003697321,"domain_scores_codex":[0.9977813,0.0004366863,0.000720756,0.0003159726,0.0004833615,0.000261894],"domain_scores_gemma":[0.9985447,0.0001330526,0.0003978619,0.0002318114,0.0002850665,0.0004074941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.03024906,0.004078742,0.4118563,0.002162871,0.002345789,0.009290407,0.01484261,0.2367509,0.2144866,0.0002126265,0.0002494137,0.07347457],"study_design_scores_gemma":[0.004225296,0.0002545828,0.1976694,0.000246131,0.001399141,0.0001998447,0.002703924,0.7910609,0.001643606,0.0001279629,0.0001565369,0.0003126596],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868867,0.01016756,0.0008424906,0.001514451,0.00006672004,0.0004111517,0.00002478933,0.00001396455,0.00007217943],"genre_scores_gemma":[0.9982721,0.0001800635,0.0001819894,0.000999651,0.0002857471,0.000007602854,0.0000337567,0.00002776929,0.00001136467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5543099,"threshold_uncertainty_score":0.7521108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415744251300859,"score_gpt":0.2641578526374065,"score_spread":0.2500004101243979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}