{"id":"W3112757605","doi":"10.1093/neuonc/noaa222.223","title":"ETMR-20. IMPACT OF HIGH DOSE CHEMOTHERAPY WITH AND WITHOUT METHOTREXATE (MTX) ON OUTCOME OF PATIENTS WITH EMBRYONAL TUMORS WITH MULTI-LAYERED ROSETTES (ETMRs): A REPORT FROM CHILDREN’S ONCOLOGY GROUP PHASE III TRIAL ACNS0334","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Medulloblastoma; Chemotherapy; Methotrexate; Regimen; Oncology; Internal medicine; Radiation therapy; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002088565,0.0006206019,0.002359411,0.0002098006,0.00007266432,0.0000137161,0.0001669261,0.0002638563,0.0001074835],"category_scores_gemma":[0.0001807155,0.0003645468,0.0002061939,0.0003544218,0.0004226229,0.0001005158,0.00006550852,0.0004840585,0.000002495416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002643978,"about_ca_system_score_gemma":0.0005090032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009334757,"about_ca_topic_score_gemma":0.0002061901,"domain_scores_codex":[0.9965723,0.0003475154,0.001042546,0.0009960594,0.0005595747,0.0004820243],"domain_scores_gemma":[0.9967175,0.0005754253,0.001427397,0.000554488,0.0002381389,0.0004870716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.275366,0.009981086,0.6841903,0.00002687136,0.001637933,0.001329008,0.0006116058,0.00006636905,0.02141125,0.000007473332,0.0001580514,0.005214024],"study_design_scores_gemma":[0.3572791,0.103481,0.5276843,0.00006965119,0.0008534705,0.0002343318,0.00004796713,0.00009595486,0.009814233,0.000004870688,0.0001615704,0.0002736002],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944478,0.00005110048,0.0000706506,0.001840483,0.0001043145,0.002951876,0.0004135781,0.00006322052,0.00005703299],"genre_scores_gemma":[0.9930302,0.00002450075,0.00444427,0.001504487,0.0001604288,0.000197705,0.0005283651,0.0001053716,0.000004664812],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.156506,"threshold_uncertainty_score":0.9998807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03053796587446334,"score_gpt":0.3423896198946818,"score_spread":0.3118516540202185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}