{"id":"W3112757605","doi":"10.1093/neuonc/noaa222.223","title":"ETMR-20. IMPACT OF HIGH DOSE CHEMOTHERAPY WITH AND WITHOUT METHOTREXATE (MTX) ON OUTCOME OF PATIENTS WITH EMBRYONAL TUMORS WITH MULTI-LAYERED ROSETTES (ETMRs): A REPORT FROM CHILDREN’S ONCOLOGY GROUP PHASE III TRIAL ACNS0334","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Medulloblastoma; Chemotherapy; Methotrexate; Regimen; Oncology; Internal medicine; Radiation therapy; Surgery; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001362439,0.0003410362,0.0008272033,0.000245761,0.0002378586,0.0005810781,0.0005260219,0.0005531984,0.001459572],"category_scores_gemma":[0.001253349,0.0001330574,0.0008661588,0.0002538975,0.0003240677,0.0005216656,0.0002546143,0.001537504,0.0002687059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007253803,"about_ca_system_score_gemma":0.000576995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006642865,"about_ca_topic_score_gemma":0.00167052,"domain_scores_codex":[0.9995031,0.0002635492,0.00004126049,0.00007748482,0.00005127137,0.00006335584],"domain_scores_gemma":[0.9985985,0.0003549468,0.000319256,0.0001407138,0.0000562542,0.0005302522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7164571,0.01658356,0.07405192,0.0003691662,0.001971367,0.0003464806,0.0002884231,0.003934535,0.02939811,0.0003477199,0.003823779,0.152428],"study_design_scores_gemma":[0.1232074,0.6146761,0.2414502,0.00008436213,0.001322303,0.001078794,0.0001275687,0.00397618,0.00890102,0.0003855448,0.004735915,0.00005449816],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977474,0.0008313775,0.00008802443,0.000117442,0.00002720441,0.00007250546,0.0004237048,0.00001286636,0.0006795352],"genre_scores_gemma":[0.9973899,0.0003370781,0.0002084856,0.000173597,0.0000429595,0.0001111468,0.001273806,0.000007428738,0.0004557053],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459572,"threshold_uncertainty_score":0.007205367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03053796587446334,"score_gpt":0.3423896198946818,"score_spread":0.3118516540202185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}