{"id":"W3112773133","doi":"10.7554/elife.62816","title":"Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones","year":2020,"lang":"en","type":"article","venue":"eLife","topic":"Vibrio bacteria research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; University of Manitoba; McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Max-Planck-Gesellschaft","keywords":"Effector; Chaperone (clinical); Secretion; Biology; Type VI secretion system; Cell biology; Transmembrane protein; Transmembrane domain; Type three secretion system; Transport protein; Biochemistry; Virulence; Membrane; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001022962,0.0001982451,0.0001819534,0.0001149387,0.0002834644,0.0004004542,0.0003592981,0.0004146322,0.000684458],"category_scores_gemma":[0.0002220913,0.00009549092,0.0002202804,0.00008926528,0.0002350164,0.0001900453,0.0002271857,0.0003489996,0.0005851653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003711048,"about_ca_system_score_gemma":0.0003338703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000391532,"about_ca_topic_score_gemma":0.000338192,"domain_scores_codex":[0.9999239,0.000009062564,0.000006510541,0.00001895378,0.00002041871,0.0000211261],"domain_scores_gemma":[0.9998937,0.00001086971,0.00003142796,0.000008818673,0.00001787933,0.00003729202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003480622,0.00009783499,0.004100467,0.00007839177,0.00001315118,0.0007908041,0.00005649224,0.001000489,0.9879172,0.002573203,0.000294137,0.002729754],"study_design_scores_gemma":[0.0001934119,0.001236425,0.07424209,0.00005902658,0.00007347525,0.003463052,0.0004911014,0.04177011,0.8641614,0.004278504,0.009979762,0.00005163716],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950589,0.0006234256,0.002474612,0.0001787203,0.00003538773,0.00001343389,0.0000772432,0.00007972617,0.001458584],"genre_scores_gemma":[0.9982036,0.0001786812,0.0009201048,0.00006133974,0.000008571581,0.000004633326,0.0001849562,0.000007149499,0.0004308983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000684458,"threshold_uncertainty_score":0.002692521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01981576011389167,"score_gpt":0.2586303334798921,"score_spread":0.2388145733660005,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}