{"id":"W3112796825","doi":"10.1098/rsob.200188","title":"The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead","year":2020,"lang":"en","type":"article","venue":"Open Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"APOBEC; Biology; Cytidine deaminase; Somatic cell; Genetics; Cytidine; Genome instability; Mutation; Cancer research; Somatic hypermutation; APOBEC3G; Context (archaeology); Cancer; Deamination; Cytosine; Enzyme; DNA; DNA damage; Gene; Biochemistry; Genome; Antibody; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414011,0.0001014872,0.0001178035,0.000009326996,0.000162109,0.0000481819,0.0002754456,0.00008856827,0.000006086794],"category_scores_gemma":[0.0003678807,0.00007677828,0.00002478002,0.00005941959,0.00007664272,0.000002890179,0.0003975209,0.00009261487,0.000004022141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005695346,"about_ca_system_score_gemma":0.00003167229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001710658,"about_ca_topic_score_gemma":0.0002677636,"domain_scores_codex":[0.9993351,0.0000562004,0.0001513346,0.0002535055,0.00002384314,0.0001800533],"domain_scores_gemma":[0.9996154,0.00008986592,0.00004411432,0.0001468226,0.00002367882,0.00008007097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0000464463,0.000004584534,0.8859698,0.00001601825,0.00004667271,0.000001573654,0.00008172323,0.00004390749,0.0436295,0.0002303829,0.0006354754,0.06929388],"study_design_scores_gemma":[0.0008334224,0.000592917,0.8396261,0.00003837936,0.00005362319,0.00001910302,0.0001856552,0.0003563465,0.06699587,0.0002145443,0.09070521,0.0003788274],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880505,0.00511493,0.004044493,0.00200351,0.000072218,0.0002004419,0.00001954707,0.00001001654,0.0004844114],"genre_scores_gemma":[0.9985404,0.0003209142,0.0003998703,0.0002050993,0.0002847398,0.00002965675,0.00005765913,0.00001241965,0.0001492574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09006973,"threshold_uncertainty_score":0.3130927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05562107586912132,"score_gpt":0.3957623141141069,"score_spread":0.3401412382449856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}