{"id":"W3112796825","doi":"10.1098/rsob.200188","title":"The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead","year":2020,"lang":"en","type":"article","venue":"Open Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research; Saskatchewan Health Research Foundation","keywords":"APOBEC; Biology; Cytidine deaminase; Somatic cell; Genetics; Cytidine; Genome instability; Mutation; Cancer research; Somatic hypermutation; APOBEC3G; Context (archaeology); Cancer; Deamination; Cytosine; Enzyme; DNA; DNA damage; Gene; Biochemistry; Genome; Antibody; B cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007300135,0.0003525451,0.0009087421,0.000564368,0.0004552601,0.001601031,0.0004913627,0.002271786,0.003451148],"category_scores_gemma":[0.000890077,0.0001606536,0.000344892,0.000960395,0.001098401,0.003258608,0.0008787275,0.004232588,0.0008924158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006133199,"about_ca_system_score_gemma":0.001304877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000830174,"about_ca_topic_score_gemma":0.001533512,"domain_scores_codex":[0.9997709,0.00006043704,0.00001833392,0.00004231407,0.00007199307,0.00003592443],"domain_scores_gemma":[0.9991147,0.0004794323,0.00007012748,0.00003065899,0.000177712,0.0001274023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003626088,0.0001271366,0.002094696,0.006252911,0.0001455457,0.00138062,0.0004658589,0.0004376718,0.01409494,0.06187293,0.08049049,0.8322746],"study_design_scores_gemma":[0.00002395188,0.0002528321,0.005020816,0.001791767,0.00008750919,0.003441042,0.0006639453,0.0003268712,0.002069799,0.05992747,0.9263226,0.00007131321],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001280931,0.9656515,0.001331082,0.02727606,0.002396813,0.000005182513,0.00004786041,0.0000308005,0.001979691],"genre_scores_gemma":[0.01042453,0.9721206,0.001514363,0.00782711,0.004804449,0.00001015575,0.00007461891,0.00001413444,0.003209941],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003451148,"threshold_uncertainty_score":0.01154518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05562107586912132,"score_gpt":0.3957623141141069,"score_spread":0.3401412382449856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}