{"id":"W3112811149","doi":"10.1038/s41467-020-19810-w","title":"PD-L1 blockade in combination with inhibition of MAPK oncogenic signaling in patients with advanced melanoma","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital; Princess Margaret Cancer Centre","funders":"National Cancer Institute; Parker Institute for Cancer Immunotherapy; AstraZeneca; National Institutes of Health; Cancer Research Institute","keywords":"Blockade; Melanoma; MAPK/ERK pathway; Cancer research; Medicine; Signal transduction; Biology; Bioinformatics; Pharmacology; Cell biology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008425175,0.000421255,0.0008045806,0.0002036071,0.0001982176,0.0004320164,0.0002647339,0.0002960949,0.0008602565],"category_scores_gemma":[0.0005325236,0.0001764774,0.0004317426,0.0002249661,0.0001757189,0.0003878645,0.0001922955,0.0008587443,0.00020759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005541368,"about_ca_system_score_gemma":0.0005889469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005183496,"about_ca_topic_score_gemma":0.002003307,"domain_scores_codex":[0.9997695,0.0001120198,0.00001476277,0.00003809643,0.00002825303,0.00003741256],"domain_scores_gemma":[0.9997571,0.00005804399,0.00005161776,0.00001345581,0.00001400873,0.0001057078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1494251,0.02225033,0.1050222,0.0008110364,0.001117305,0.0009571841,0.0003996074,0.005123802,0.08714262,0.0003447388,0.007431761,0.6199742],"study_design_scores_gemma":[0.1339149,0.482878,0.3095811,0.0002248748,0.001580374,0.003194184,0.0003042658,0.01415177,0.02793618,0.001241808,0.02489832,0.00009436526],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934454,0.003478094,0.0003236699,0.000423911,0.00003830397,0.0002111335,0.00020874,0.00004609154,0.001824703],"genre_scores_gemma":[0.9973567,0.0009882916,0.0006271724,0.0002334827,0.00004404252,0.00009335742,0.0002467659,0.000004263375,0.0004060701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008602565,"threshold_uncertainty_score":0.004455686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01135901773112329,"score_gpt":0.2605725217600469,"score_spread":0.2492135040289236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}