{"id":"W3112830085","doi":"10.1186/s13148-020-00984-5","title":"Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer’s disease and implicate its dynamic role in disease progression","year":2020,"lang":"en","type":"article","venue":"Clinical Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Servier; Eisai; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Quantitative trait locus; Disease; Trait; Human genetics; Locus (genetics); Peripheral; Peripheral blood; Biology; Medicine; Genetics; Internal medicine; Gene; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007956059,0.0002383335,0.0002537332,0.000437988,0.0002246371,0.0003012225,0.0002681242,0.0002365897,0.00250228],"category_scores_gemma":[0.001566195,0.0001304883,0.0003525495,0.0006548766,0.0001501307,0.0001374937,0.0003009091,0.0003348147,0.0003332171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002299044,"about_ca_system_score_gemma":0.0001824395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002310782,"about_ca_topic_score_gemma":0.003231096,"domain_scores_codex":[0.9997706,0.00004217072,0.00001335935,0.0001096144,0.00004427891,0.00001992551],"domain_scores_gemma":[0.9990537,0.0003052952,0.0003557416,0.0001009078,0.0001101378,0.0000742289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006536106,0.00008094435,0.9032374,0.0001135756,0.00043131,0.0002232651,0.0002424865,0.0005413721,0.06576071,0.0002435814,0.0007152404,0.02775643],"study_design_scores_gemma":[0.00001766071,0.0002107247,0.9890513,0.00001328628,0.0001146014,0.0005030824,0.00005091694,0.0006666126,0.006966218,0.0003664034,0.002031709,0.000007346825],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800159,0.001191097,0.01143568,0.0001084432,0.00001260344,0.00002447137,0.006237498,0.00008998303,0.0008843591],"genre_scores_gemma":[0.9893854,0.0004582023,0.005819631,0.00009320208,0.00001776618,0.0000625252,0.003504026,0.00002153604,0.0006375891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00250228,"threshold_uncertainty_score":0.008370996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1494110351952993,"score_gpt":0.4283213286511658,"score_spread":0.2789102934558665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}