{"id":"W3112834042","doi":"10.1016/j.celrep.2020.108455","title":"Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells","year":2020,"lang":"en","type":"article","venue":"Cell Reports","topic":"Liver physiology and pathology","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Key Research and Development Program of China; Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China","keywords":"Cell biology; Endoderm; Stem cell; Biology; In vitro; In vivo; Transcriptome; Hepatocyte; Mesenchymal stem cell; Hepatic stellate cell; Embryonic stem cell; Endocrinology; Biochemistry; Gene; Biotechnology; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003111888,0.0002078486,0.0001541364,0.000219894,0.0001209075,0.0002907094,0.0001522634,0.000195751,0.001005602],"category_scores_gemma":[0.0001652505,0.0001046599,0.0002043319,0.0001001233,0.0001809727,0.0001414438,0.0003477373,0.0003892931,0.0004148669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001071058,"about_ca_system_score_gemma":0.0002286806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001790305,"about_ca_topic_score_gemma":0.0005636697,"domain_scores_codex":[0.9998871,0.00002179107,0.00001427994,0.00001851387,0.00004822187,0.000009963605],"domain_scores_gemma":[0.9998807,0.00003557704,0.00001845618,0.00002483941,0.00001802453,0.0000224391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003685186,0.00001718635,0.0004097287,0.00003096456,0.000004611398,0.0000868628,0.00002661559,0.0001204164,0.9952566,0.0002383697,0.00007953005,0.003692211],"study_design_scores_gemma":[0.00001789154,0.0001851219,0.002306407,0.000007177235,0.00001515877,0.0002794286,0.00003970488,0.0009144344,0.9884444,0.0001118049,0.007673238,0.000005139783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.891094,0.00216992,0.09792536,0.0003253393,0.0001348837,0.0005486805,0.001390542,0.0004098121,0.006001539],"genre_scores_gemma":[0.9457108,0.001519763,0.04638019,0.0001040027,0.00003463869,0.0002215155,0.002118661,0.00006592509,0.003844455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001005602,"threshold_uncertainty_score":0.003364027,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03633937902399526,"score_gpt":0.2276885961434623,"score_spread":0.1913492171194671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}