{"id":"W3112841125","doi":"10.1002/alz.040308","title":"Synaptic stimulation protects against pathological tau by enhancing lysosomal degradation","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Stimulation; Neuroscience; Entorhinal cortex; Autophagy; Deep brain stimulation; Synapse; Biology; Cell biology; Medicine; Hippocampus; Internal medicine; Parkinson's disease; Disease; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001590606,0.0004483126,0.0005527165,0.0004152097,0.0001945201,0.0004695582,0.0002015767,0.000334922,0.001782386],"category_scores_gemma":[0.0001412961,0.0001206353,0.0004867361,0.0001955809,0.0002572862,0.0002564202,0.0001869149,0.0007466915,0.0006135111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002979729,"about_ca_system_score_gemma":0.0002661765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003999538,"about_ca_topic_score_gemma":0.0007692343,"domain_scores_codex":[0.9998438,0.00001713303,0.00001905326,0.00004266638,0.00003931124,0.00003790121],"domain_scores_gemma":[0.9999065,0.000009393855,0.00003011253,0.00001170336,0.00002185608,0.0000204024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002216592,0.0000387058,0.0001265318,0.000181902,0.00001305626,0.00003512098,0.000009611976,0.00003828581,0.9975236,0.00005952009,0.00008627677,0.001665715],"study_design_scores_gemma":[0.000033902,0.000597364,0.004432246,0.00004293982,0.00007211786,0.0001951365,0.00003509934,0.0004037504,0.991339,0.000117948,0.002721417,0.00000896803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716809,0.01382825,0.007665244,0.000257762,0.0001694459,0.00009931177,0.001913497,0.0004520375,0.003933427],"genre_scores_gemma":[0.9877224,0.004532761,0.003461291,0.0001261739,0.00003475087,0.0001198532,0.001338019,0.00004783515,0.002616846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001782386,"threshold_uncertainty_score":0.00596267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03986783364949485,"score_gpt":0.296349797795426,"score_spread":0.2564819641459312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}