{"id":"W3112852434","doi":"10.1002/alz.044985","title":"A blood cholesterol polygenic score in two independent AD cohorts","year":2020,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alzheimer Society of Canada; McGill University; Douglas College","funders":"","keywords":"Medicine; Internal medicine; Cohort; Explained variation; Analysis of variance; Cholesterol; Correlation; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004105564,0.0009146698,0.0005917177,0.001894411,0.001077545,0.001044918,0.0007318632,0.0006983209,0.001870006],"category_scores_gemma":[0.006811118,0.000348887,0.001733095,0.00230351,0.0005243164,0.0003487429,0.00150498,0.001079941,0.0002479595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005238338,"about_ca_system_score_gemma":0.000741554,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01998815,"about_ca_topic_score_gemma":0.01478908,"domain_scores_codex":[0.9978449,0.0008208787,0.0001412902,0.0007660441,0.000235781,0.0001910447],"domain_scores_gemma":[0.9961797,0.001035557,0.0009475793,0.0008360037,0.0005650298,0.0004362031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006849004,0.00006880306,0.9925309,0.00002130001,0.001189848,0.00016137,0.0001327915,0.0009174538,0.0005213127,0.0002539452,0.0005551141,0.002962262],"study_design_scores_gemma":[0.00006547599,0.0002225716,0.9898582,0.00001650251,0.0009190731,0.0003059948,0.0001197734,0.006856716,0.0002293421,0.000531454,0.0008462697,0.00002853663],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948401,0.0001305355,0.002242015,0.00008450298,0.00001820113,0.00003815057,0.002337634,0.0000303427,0.0002786329],"genre_scores_gemma":[0.9945297,0.00005218011,0.00155961,0.00002730757,0.00001352269,0.00006955274,0.003440944,0.00001201498,0.0002953637],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01998815,"threshold_uncertainty_score":0.0397436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04084147610992476,"score_gpt":0.3172102016047479,"score_spread":0.2763687254948231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}