{"id":"W3112886802","doi":"10.21203/rs.3.rs-48667/v1","title":"CellectSeq: In Silico Discovery of Antibodies Targeting Integral Membrane Proteins Combining In Situ Selections of Phage Displayed Synthetic Antibodies and Next-Generation Sequencing","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"In silico; Phage display; Computational biology; Antibody; In situ; Biology; Chemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001667967,0.0008895243,0.0007354089,0.0006106555,0.0003166089,0.001312992,0.0006040242,0.0005586429,0.001526484],"category_scores_gemma":[0.001287894,0.0003568808,0.0006578016,0.0003861882,0.0003011565,0.0003490306,0.0005178921,0.0006336442,0.0007558052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004286289,"about_ca_system_score_gemma":0.0008004428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008614566,"about_ca_topic_score_gemma":0.001278119,"domain_scores_codex":[0.9994911,0.00009505609,0.00003813718,0.0001461373,0.000183722,0.00004589227],"domain_scores_gemma":[0.9994374,0.0003366195,0.000066131,0.00004411437,0.00007622156,0.00003943511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005973183,0.0001397755,0.00799651,0.0004473882,0.0002737886,0.0003090397,0.0001248836,0.02618371,0.9100738,0.00249673,0.00323787,0.04811911],"study_design_scores_gemma":[0.00007641773,0.0002548502,0.003369214,0.00001687453,0.00009537006,0.0002925717,0.00003928197,0.372593,0.611388,0.001248926,0.01057424,0.00005127626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3716477,0.0006969411,0.6110676,0.0002227272,0.0001445984,0.000309102,0.00381815,0.009436527,0.002656637],"genre_scores_gemma":[0.3751278,0.0004629385,0.6138788,0.0003202954,0.00003769437,0.0004381711,0.006658134,0.0008793742,0.002196852],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.001667967,"threshold_uncertainty_score":0.00882113,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1244539933822436,"score_gpt":0.3781298282292752,"score_spread":0.2536758348470316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}