{"id":"W3112934313","doi":"10.1038/s41591-021-01406-6","title":"Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade","year":2021,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":415,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; McGill University Health Centre","funders":"Moonshot Research and Development Program; National Cancer Institute; Medical Research Council; University of Texas MD Anderson Cancer Center; Swiss Bridge Foundation; Cancer Prevention and Research Institute of Texas; Institut Gustave-Roussy; Fondation de France; Ligue Contre le Cancer; Horizon 2020 Framework Programme; Fondation pour la Recherche Médicale; CHIST-ERA; Agence Nationale de la Recherche; Memorial Sloan-Kettering Cancer Center; Fondation Philanthropia; Association pour la Recherche sur le Cancer; Seerave Foundation; Stand Up To Cancer; Chancellerie des Universités de Paris; AIM at Melanoma; University of Toronto; Melanoma Research Alliance; Labex Immuno-Oncology; National Institutes of Health; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; National Health and Medical Research Council; Institut National Du Cancer; Fonds de Recherche du Québec - Santé; Institut National de la Santé et de la Recherche Médicale; E-Rare; American Association for Cancer Research; U.S. Department of Health and Human Services","keywords":"CTLA-4; Blockade; Gut flora; Toxicity; Medicine; Immunology; Biology; Internal medicine; Immune system; Receptor; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187945,0.0002491579,0.0004159454,0.0002605302,0.0001621487,0.000444313,0.00009587093,0.0003690099,0.001391895],"category_scores_gemma":[0.0004768585,0.0001831908,0.0002722203,0.0002211196,0.0002161435,0.0001936338,0.0003397546,0.0007045628,0.0002013767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002852189,"about_ca_system_score_gemma":0.0002463662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003339031,"about_ca_topic_score_gemma":0.0006144968,"domain_scores_codex":[0.9997519,0.00005749068,0.0000141135,0.00003959972,0.00005513324,0.00008182435],"domain_scores_gemma":[0.999637,0.00003514461,0.0001843338,0.00002164457,0.00002969478,0.00009222744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01247078,0.0004487321,0.09499177,0.0001075133,0.0002175086,0.0004433576,0.00006931251,0.0005200814,0.8676577,0.000163651,0.0005148266,0.02239481],"study_design_scores_gemma":[0.0002320533,0.005048406,0.9075103,0.00004397641,0.0003476265,0.002267099,0.0002744667,0.002762744,0.07853038,0.0005329341,0.0024254,0.00002463578],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99841,0.0005701876,0.0002748995,0.00008098943,0.00001399154,0.0000103661,0.0001186666,0.00001665353,0.0005042077],"genre_scores_gemma":[0.9988915,0.0001935183,0.0001868417,0.00007699807,0.000007674378,0.00001428339,0.0001415601,0.000005613389,0.0004820171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001391895,"threshold_uncertainty_score":0.004656315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004640555779012037,"score_gpt":0.2485048955504778,"score_spread":0.2438643397714657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}