{"id":"W3112934313","doi":"10.1038/s41591-021-01406-6","title":"Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade","year":2021,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":415,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; McGill University Health Centre","funders":"Moonshot Research and Development Program; National Cancer Institute; Medical Research Council; University of Texas MD Anderson Cancer Center; Swiss Bridge Foundation; Cancer Prevention and Research Institute of Texas; Institut Gustave-Roussy; Fondation de France; Ligue Contre le Cancer; Horizon 2020 Framework Programme; Fondation pour la Recherche Médicale; CHIST-ERA; Agence Nationale de la Recherche; Memorial Sloan-Kettering Cancer Center; Fondation Philanthropia; Association pour la Recherche sur le Cancer; Seerave Foundation; Stand Up To Cancer; Chancellerie des Universités de Paris; AIM at Melanoma; University of Toronto; Melanoma Research Alliance; Labex Immuno-Oncology; National Institutes of Health; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; National Health and Medical Research Council; Institut National Du Cancer; Fonds de Recherche du Québec - Santé; Institut National de la Santé et de la Recherche Médicale; E-Rare; American Association for Cancer Research; U.S. Department of Health and Human Services","keywords":"CTLA-4; Blockade; Gut flora; Toxicity; Medicine; Immunology; Biology; Internal medicine; Immune system; Receptor; T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001757125,0.0002211469,0.000325057,0.00005607724,0.0001130643,0.00001410448,0.0001331664,0.0005781493,0.00005396922],"category_scores_gemma":[0.000450848,0.0001641813,0.00003337929,0.0002659711,0.0001071764,0.000002008808,0.0001040162,0.0005253952,0.000002635116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002818645,"about_ca_system_score_gemma":0.0001218636,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001154856,"about_ca_topic_score_gemma":0.0004557571,"domain_scores_codex":[0.9987827,0.00007621112,0.0001810052,0.0004862341,0.0001510007,0.0003228651],"domain_scores_gemma":[0.9990819,0.00003095368,0.00009469671,0.0003127452,0.000269431,0.0002103154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001330573,0.00007426694,0.002124841,0.0000359797,0.00007775298,0.00004660576,0.00007781032,0.000002258438,0.9537102,0.0000257776,0.04355698,0.0001344621],"study_design_scores_gemma":[0.004153623,0.001493406,0.2816207,0.0005409286,0.0001195677,0.0001198779,0.0002577759,0.000004480706,0.6306587,0.0000349392,0.08050718,0.0004889161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798141,0.006847755,0.00003534392,0.01220552,0.0002262748,0.0002242576,0.00005710591,0.00002227104,0.0005673714],"genre_scores_gemma":[0.9844887,0.0001722464,0.0002864207,0.01227476,0.0003308712,0.000004981375,0.0004406964,0.00002592782,0.001975355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3230515,"threshold_uncertainty_score":0.6695119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004640555779012037,"score_gpt":0.2485048955504778,"score_spread":0.2438643397714657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}