{"id":"W3112951837","doi":"10.1126/science.abb4309","title":"HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells","year":2021,"lang":"en","type":"article","venue":"Science","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":376,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute on Aging; Damon Runyon Cancer Research Foundation; Natural Sciences and Engineering Research Council of Canada; National Science Foundation; Pew Charitable Trusts; NOMIS Stiftung","keywords":"RNA; Neurodegeneration; Stress granule; Proteasome; Cytoplasm; Chemistry; Biophysics; Acetylation; Adenosine triphosphate; Cell biology; Biochemistry; Biology; Messenger RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003551542,0.0001218319,0.0001201095,0.00003741342,0.0002659416,0.00009560124,0.0009118087,0.0001003355,0.0003461],"category_scores_gemma":[0.0007549306,0.0001141723,0.00005333662,0.0005333893,0.0007375384,0.00001496478,0.0009438082,0.0001457027,0.0001555551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004654778,"about_ca_system_score_gemma":0.0006671391,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003656982,"about_ca_topic_score_gemma":0.00004134402,"domain_scores_codex":[0.9981183,0.00006978535,0.0001596182,0.0006293863,0.0005060431,0.00051684],"domain_scores_gemma":[0.9986528,0.00000974974,0.00002203761,0.0008461335,0.000225186,0.0002441086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000349253,0.00004502385,0.00006017223,0.00001241753,0.000004410719,0.00002364079,0.00007039664,0.00001093411,0.9931055,0.0002123859,0.0003109558,0.006109194],"study_design_scores_gemma":[0.0002253093,0.000451298,0.0007437787,0.000009267371,0.000001998094,0.00002118973,0.00009094445,0.00009853367,0.9409353,0.0001377113,0.05714065,0.0001440389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908343,0.0008983711,0.001727683,0.001645345,0.0001678426,0.0001355489,0.000004075534,0.0000198486,0.004566986],"genre_scores_gemma":[0.9898202,0.0002531979,0.008303482,0.0004494523,0.0002171953,0.00001319608,0.000005718298,0.00001706875,0.0009204787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05682969,"threshold_uncertainty_score":0.465581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01178272439811467,"score_gpt":0.2841216006703373,"score_spread":0.2723388762722226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}