{"id":"W3112961014","doi":"10.1136/jitc-2020-001849","title":"Galectin-9 expression defines exhausted T cells and impaired cytotoxic NK cells in patients with virus-associated solid tumors","year":2020,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canadian Institutes of Health Research; University of Alberta; Alberta Cancer Foundation","keywords":"TIGIT; Cytotoxic T cell; T cell; Downregulation and upregulation; IL-2 receptor; Cancer research; Interleukin 21; Immunology; Galectin; CD8; Biology; Medicine; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701997,0.0002311985,0.0005529953,0.0001106707,0.0001779646,0.00001816933,0.0001797534,0.0002127731,0.0003554205],"category_scores_gemma":[0.00001891981,0.0001705789,0.0001111736,0.0001883536,0.0001300785,0.00009636216,0.00002558524,0.0003542516,0.000002503263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009114926,"about_ca_system_score_gemma":0.0001366704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000149954,"about_ca_topic_score_gemma":0.0001369385,"domain_scores_codex":[0.9986565,0.0001329717,0.0005154786,0.000245863,0.00006038753,0.000388844],"domain_scores_gemma":[0.9990349,0.00007835771,0.0005512199,0.0001079391,0.000186725,0.00004090481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005441725,0.0001761,0.03922832,0.00003175296,0.000240493,0.000001163688,0.0007638326,0.00005213175,0.9493032,0.00000116761,0.001907095,0.002853078],"study_design_scores_gemma":[0.0120958,0.002921684,0.1035956,0.0002378775,0.00003652796,0.000006228745,0.0001465664,0.000007000692,0.8753477,0.00002905528,0.005309327,0.000266603],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938427,0.004809998,0.00004527088,0.0001397319,0.0005621383,0.0004374347,0.0001235592,0.00001892425,0.0000202266],"genre_scores_gemma":[0.9976428,0.001464153,0.00008152178,0.000444691,0.00004476937,0.00004287105,0.00001816211,0.0000376822,0.0002234124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07395545,"threshold_uncertainty_score":0.6956006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0109078295511333,"score_gpt":0.2508194246248309,"score_spread":0.2399115950736976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}