{"id":"W3113000665","doi":"10.1093/neuonc/noaa215.846","title":"STEM-29. THE HISTONE VARIANT macroH2A2 ORCHESTRATES AN ACTIONABLE CHROMATIN PROGRAM OF STEMNESS IN GLIOBLASTOMA","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Calgary","funders":"","keywords":"Chromatin; Epigenetics; Biology; Histone; Epigenomics; Reprogramming; Cancer research; Transcription factor; Glioblastoma; Transcriptome; Stem cell; Computational biology; Cell biology; Cell; Genetics; DNA methylation; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126349,0.0002180636,0.0002580374,0.0002675741,0.0001587409,0.0003140979,0.0001120397,0.0001578417,0.001669983],"category_scores_gemma":[0.00008301358,0.0001118929,0.0001930182,0.0002043944,0.0001700353,0.0001073481,0.0001626939,0.0002024568,0.00032685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002790834,"about_ca_system_score_gemma":0.0001992695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000962076,"about_ca_topic_score_gemma":0.002832122,"domain_scores_codex":[0.9999315,0.000006593878,0.00000500657,0.00002205998,0.00002146434,0.00001343049],"domain_scores_gemma":[0.9999342,0.000006997277,0.000020067,0.00000823423,0.000009146201,0.00002131302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001107331,0.000006784887,0.001136528,0.00002823396,0.00001266235,0.00004401719,0.000007924185,0.0001251082,0.9964484,0.00006500804,0.00008716418,0.001927381],"study_design_scores_gemma":[0.00001682742,0.0003309476,0.03460158,0.000006766116,0.00003719658,0.0002949753,0.00004626783,0.001457945,0.9573946,0.0001461503,0.005657461,0.000009345464],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833566,0.002229078,0.006356502,0.0001315551,0.00004090609,0.00005513111,0.005749299,0.000291049,0.001789826],"genre_scores_gemma":[0.9921373,0.0004909938,0.001592461,0.0000954542,0.000008232822,0.00002978584,0.003639908,0.00003477253,0.001971131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001669983,"threshold_uncertainty_score":0.005586624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906152914665282,"score_gpt":0.2949411824889666,"score_spread":0.2758796533423138,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}