{"id":"W3113008414","doi":"","title":"PBRM1 deficiency in cancer is synthetic lethal with DNA repair inhibitors","year":2020,"lang":"en","type":"preprint","venue":"HAL (Le Centre pour la Communication Scientifique Directe)","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"DNA repair; Cancer; Cancer research; DNA; Genetics; Medicine; Biology; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002032693,0.0003335188,0.0003199144,0.0003431322,0.0001355902,0.0003199278,0.0001994264,0.0003353284,0.002603628],"category_scores_gemma":[0.0001961712,0.0001852547,0.0001999904,0.000173692,0.0003072081,0.0001616945,0.0002597978,0.0005836528,0.0005555426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002049092,"about_ca_system_score_gemma":0.00023107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003023968,"about_ca_topic_score_gemma":0.0004837782,"domain_scores_codex":[0.9998174,0.00004355229,0.00001668679,0.00003759766,0.00004526809,0.0000394553],"domain_scores_gemma":[0.9998345,0.00005032971,0.00004544162,0.00002546658,0.000009530741,0.00003471536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001703179,0.00002715365,0.0001253287,0.00002515704,0.000005318119,0.00005542981,0.000006466453,0.0001227266,0.9972964,0.0002403263,0.00009148344,0.001833881],"study_design_scores_gemma":[0.00001563039,0.0002242401,0.001333174,0.000003585342,0.000006026686,0.0003130861,0.00001101555,0.0005221373,0.995517,0.00005887665,0.001992672,0.000002577128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848846,0.001871045,0.006246468,0.0003274865,0.00005062378,0.0000582209,0.001067998,0.000496101,0.004997479],"genre_scores_gemma":[0.9915535,0.0006675522,0.00357166,0.00007724081,0.000009291186,0.00003764021,0.0007809029,0.00007400931,0.003228078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002603628,"threshold_uncertainty_score":0.008709967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02463917889428803,"score_gpt":0.27536363580632,"score_spread":0.250724456912032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}