{"id":"W3113017727","doi":"10.1002/anie.202005934","title":"Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B‐Cell Lymphoma Therapy","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; Danmarks Grundforskningsfond; National Research Foundation","keywords":"Glycan; CD22; Selectin; Lymphoma; B-cell lymphoma; Chemistry; Cancer research; Virology; Immunology; Biology; Biochemistry; Glycoprotein; CD20; Cell adhesion molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007472075,0.00009865849,0.0001867862,0.00007361391,0.00001568213,0.000008967879,0.00007282142,0.00005278168,0.0002509879],"category_scores_gemma":[0.00003189917,0.00008546829,0.00006063608,0.0001275237,0.00005226514,0.00007154222,0.00001645253,0.000062106,6.261707e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004859677,"about_ca_system_score_gemma":0.00006775832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002097143,"about_ca_topic_score_gemma":0.000001975687,"domain_scores_codex":[0.9992371,0.000003175436,0.0001787868,0.0001648682,0.000306169,0.0001099275],"domain_scores_gemma":[0.9993666,0.00008525352,0.00008939519,0.00007572463,0.0003020178,0.00008098743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001890478,0.0001380824,0.000568683,0.000193638,0.0001226565,0.000003335222,0.0005298952,0.00001731931,0.9924254,0.00002102182,0.001763716,0.002325736],"study_design_scores_gemma":[0.004713798,0.0009417492,0.0004254705,0.00007131176,0.00001922598,0.00001387286,0.0001137635,0.0008071706,0.9852891,0.00002511258,0.007505467,0.00007397737],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926614,0.0002004353,0.003007841,0.001109912,0.0001670061,0.0003517923,0.000088302,0.0000276806,0.002385703],"genre_scores_gemma":[0.997458,0.0004264081,0.0006120231,0.0001761867,0.0007797928,0.00003010594,0.0001308914,0.00002415195,0.0003624289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007136358,"threshold_uncertainty_score":0.3485296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069440581592122,"score_gpt":0.2679587866707847,"score_spread":0.2472643808548635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}