{"id":"W3113017727","doi":"10.1002/anie.202005934","title":"Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B‐Cell Lymphoma Therapy","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; Danmarks Grundforskningsfond; National Research Foundation","keywords":"Glycan; CD22; Selectin; Lymphoma; B-cell lymphoma; Chemistry; Cancer research; Virology; Immunology; Biology; Biochemistry; Glycoprotein; CD20; Cell adhesion molecule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008109205,0.0002319901,0.0001104975,0.000114222,0.00007371692,0.0002000098,0.0001103702,0.0001928859,0.0006429689],"category_scores_gemma":[0.00005441407,0.00006932079,0.0001282247,0.0001039246,0.0001125658,0.0001538634,0.0001947229,0.0003314511,0.0001584598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199171,"about_ca_system_score_gemma":0.0001349036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004128103,"about_ca_topic_score_gemma":0.0005139901,"domain_scores_codex":[0.9999573,0.000008813887,0.000002119683,0.000005486447,0.00001368148,0.00001255294],"domain_scores_gemma":[0.9999868,0.000001353342,0.000004611037,0.000001795402,0.000001904619,0.000003514331],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005177261,0.00002790979,0.00008647663,0.00003653151,0.000006222548,0.00005577444,0.00001495952,0.0002303795,0.9927161,0.0005138341,0.0001494749,0.006110535],"study_design_scores_gemma":[0.00002155909,0.0002771847,0.0005368438,0.000005831849,0.00001625555,0.0003043268,0.00001220645,0.001406094,0.9888427,0.00009489838,0.008477222,0.000004823719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9629692,0.009049744,0.01996791,0.0003526132,0.00009904188,0.0001080447,0.0001282169,0.0001784295,0.007146818],"genre_scores_gemma":[0.9894603,0.003252075,0.004361019,0.0000772389,0.00001300372,0.00003744666,0.00007018545,0.00001064841,0.002717934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006429689,"threshold_uncertainty_score":0.002150893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02069440581592122,"score_gpt":0.2679587866707847,"score_spread":0.2472643808548635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}