{"id":"W3113024939","doi":"10.1186/s13195-021-00873-w","title":"Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; Avid Radiopharmaceuticals; Alzheimer Nederland; GIESKES-STRIJBIS FONDS; Stichting Dioraphte; European Commission; Sanofi; Roche Nederland; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Danone; Weston Brain Institute; Biogen; ZonMw; Janssen Prevention Center; Center for Translational Molecular Medicine; Pfizer; Eli Lilly and Company","keywords":"Internal medicine; Medicine; Amyloid (mycology); Amyloidosis; Biomarker; Oncology; Cohort; Positron emission tomography; Dementia; Population; Logistic regression; Gastroenterology; Pathology; Nuclear medicine; Biology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002098034,0.0008592547,0.0004906373,0.001218864,0.0002398041,0.0007095977,0.0002405506,0.0006439154,0.001217836],"category_scores_gemma":[0.00292145,0.0002179376,0.0003394029,0.0005762766,0.0002697331,0.0004344544,0.0003249751,0.000443538,0.0005982128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001636358,"about_ca_system_score_gemma":0.0001905668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004070928,"about_ca_topic_score_gemma":0.0005738387,"domain_scores_codex":[0.9989503,0.00041847,0.0001112483,0.0002313126,0.0002415269,0.00004717572],"domain_scores_gemma":[0.9984921,0.0005118072,0.0004524347,0.0001203806,0.0002973661,0.0001258644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002099908,0.0002994863,0.916217,0.0001340307,0.0003251109,0.0003584511,0.0001635481,0.0006124994,0.0514867,0.00007772598,0.0004189861,0.02780655],"study_design_scores_gemma":[0.00006380734,0.00260007,0.9588161,0.00006060801,0.0002346525,0.004765117,0.0001533933,0.006935102,0.02454546,0.0002486234,0.001544259,0.00003273735],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913226,0.002410589,0.004075204,0.00006153764,0.0000403598,0.00005694956,0.0004807675,0.0001318281,0.001419983],"genre_scores_gemma":[0.9944897,0.0003626755,0.004069907,0.00005150543,0.00002976911,0.00004840814,0.000290278,0.000009382288,0.0006483924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002098034,"threshold_uncertainty_score":0.01109564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06975630716968556,"score_gpt":0.3821535583412259,"score_spread":0.3123972511715404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}