{"id":"W3113024939","doi":"10.1186/s13195-021-00873-w","title":"Plasma amyloid-β oligomerization assay as a pre-screening test for amyloid status","year":2021,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Janssen Pharmaceuticals; Avid Radiopharmaceuticals; Alzheimer Nederland; GIESKES-STRIJBIS FONDS; Stichting Dioraphte; European Commission; Sanofi; Roche Nederland; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Danone; Weston Brain Institute; Biogen; ZonMw; Janssen Prevention Center; Center for Translational Molecular Medicine; Pfizer; Eli Lilly and Company","keywords":"Internal medicine; Medicine; Amyloid (mycology); Amyloidosis; Biomarker; Oncology; Cohort; Positron emission tomography; Dementia; Population; Logistic regression; Gastroenterology; Pathology; Nuclear medicine; Biology; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007745055,0.0003597549,0.0003398413,0.000166572,0.0004363415,0.0001900079,0.0004127046,0.0002906517,0.0002458279],"category_scores_gemma":[0.0010883,0.0003400837,0.000258528,0.0005132057,0.0002119449,0.00002491521,0.0002282634,0.0002712184,0.00005606419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004819583,"about_ca_system_score_gemma":0.0005199366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001977468,"about_ca_topic_score_gemma":0.0001236411,"domain_scores_codex":[0.9964142,0.0004616324,0.0003795943,0.0009429713,0.000656409,0.001145166],"domain_scores_gemma":[0.9972646,0.0006813657,0.0001179421,0.0008815547,0.0007203761,0.000334127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008550695,0.0008932765,0.0398712,0.0000186215,0.002475861,0.00003137295,0.000403135,0.0001546088,0.8086708,0.0001954204,0.008201013,0.1382296],"study_design_scores_gemma":[0.002602755,0.001242997,0.01149083,0.00002266648,0.0000700341,0.0000154229,0.0002949108,0.0001999252,0.7506756,0.0001293017,0.232894,0.0003615322],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.943065,0.04107316,0.005356842,0.003825856,0.0003470583,0.003183454,0.0004170639,0.0001347144,0.002596812],"genre_scores_gemma":[0.9714705,0.01676937,0.005166968,0.0008913187,0.0004677875,0.001441898,0.001335165,0.0001567166,0.002300278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.224693,"threshold_uncertainty_score":0.9999051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06975630716968556,"score_gpt":0.3821535583412259,"score_spread":0.3123972511715404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}