{"id":"W3113029832","doi":"10.1186/s13287-020-02050-6","title":"Human multipotent mesenchymal stromal cells cytokine priming promotes RAB27B-regulated secretion of small extracellular vesicles with immunomodulatory cargo","year":2020,"lang":"en","type":"article","venue":"Stem Cell Research & Therapy","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Institute of Musculoskeletal Health and Arthritis; Canadian Institutes of Health Research","keywords":"Cell biology; Mesenchymal stem cell; Priming (agriculture); Extracellular vesicles; Secretion; Cytokine; Stromal cell; Stem cell; Microvesicles; Extracellular; Multipotent Stem Cell; Biology; Chemistry; Immunology; Progenitor cell; Cancer research; microRNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001356424,0.0002610006,0.0002027717,0.0002456715,0.00008555128,0.0002258694,0.00007973579,0.0001319688,0.001878981],"category_scores_gemma":[0.0001077012,0.00009140802,0.0002607502,0.0001569002,0.0001383314,0.0001264072,0.000224867,0.0002894254,0.0006183267],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001821225,"about_ca_system_score_gemma":0.0001742311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002252662,"about_ca_topic_score_gemma":0.0002984665,"domain_scores_codex":[0.9998688,0.00002090373,0.00001343737,0.00002944762,0.00003527597,0.00003207243],"domain_scores_gemma":[0.999913,0.00001742325,0.00002289839,0.000008782821,0.00001623142,0.0000217543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001772926,0.00002427289,0.0002581621,0.000041858,0.000003952699,0.00003506715,0.00001665449,0.00004290384,0.9979554,0.00003536083,0.00004351992,0.001365534],"study_design_scores_gemma":[0.00002127513,0.0003160642,0.004889361,0.000007204946,0.00001745987,0.0001386029,0.00002938823,0.0005622539,0.9918824,0.00002782709,0.002105235,0.000002909435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928961,0.001907878,0.003105771,0.00007650542,0.00003113928,0.00005840386,0.000601195,0.00007635439,0.001246613],"genre_scores_gemma":[0.9937546,0.001057024,0.002249462,0.00007025449,0.00001889363,0.00007904931,0.0009546044,0.00002626185,0.001789746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001878981,"threshold_uncertainty_score":0.006285787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04425098952257352,"score_gpt":0.2833526172644487,"score_spread":0.2391016277418751,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}