{"id":"W3113041328","doi":"10.2337/db20-0765","title":"Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker–Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19","year":2020,"lang":"en","type":"article","venue":"Diabetes","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada; University of Toronto; Diabetes Canada; Institute of Nutrition, Metabolism and Diabetes; Heart and Stroke Foundation of Canada","keywords":"Telmisartan; Diabetes mellitus; Ramipril; Angiotensin-converting enzyme 2; Medicine; Kidney; Internal medicine; Endocrinology; TMPRSS2; Lung; Downregulation and upregulation; Angiotensin II receptor type 1; Kidney disease; Biology; Angiotensin II; Receptor; Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000518335,0.0003984346,0.00106834,0.0002514767,0.0001682194,0.00008557401,0.0001760725,0.000221001,0.0000254569],"category_scores_gemma":[0.02735584,0.0003361095,0.0001128697,0.0004676945,0.0002611632,0.00009212644,0.0005521576,0.0005169896,0.00001586725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003345636,"about_ca_system_score_gemma":0.0002404044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007292695,"about_ca_topic_score_gemma":0.00004210195,"domain_scores_codex":[0.9971846,0.0002315881,0.0004894868,0.0008433067,0.0004949835,0.0007560055],"domain_scores_gemma":[0.9925169,0.005006333,0.0001202784,0.0003292526,0.0001371659,0.001890106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001299999,0.00004286378,0.9777709,0.001417076,0.000237515,0.0001106844,0.002524801,0.000008043151,0.01512378,0.000005041979,0.002371612,0.0002576721],"study_design_scores_gemma":[0.004561041,0.0007677015,0.9669672,0.001649693,0.000395612,0.000002387238,0.00109479,0.01004842,0.008228138,0.000008754673,0.005662571,0.0006137157],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9604083,0.0009542906,0.00001641759,0.03695224,0.0000505409,0.00125215,0.0001606156,0.0001580767,0.00004736439],"genre_scores_gemma":[0.9877495,0.000155435,0.0002189835,0.01150049,0.000099264,0.00003930415,0.00006013976,0.00005386945,0.00012302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02734119,"threshold_uncertainty_score":0.9999091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0523420382874244,"score_gpt":0.3451229231479734,"score_spread":0.292780884860549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}