{"id":"W3113041328","doi":"10.2337/db20-0765","title":"Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker–Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19","year":2020,"lang":"en","type":"article","venue":"Diabetes","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Kidney Foundation of Canada; University of Toronto; Diabetes Canada; Institute of Nutrition, Metabolism and Diabetes; Heart and Stroke Foundation of Canada","keywords":"Telmisartan; Diabetes mellitus; Ramipril; Angiotensin-converting enzyme 2; Medicine; Kidney; Internal medicine; Endocrinology; TMPRSS2; Lung; Downregulation and upregulation; Angiotensin II receptor type 1; Kidney disease; Biology; Angiotensin II; Receptor; Coronavirus disease 2019 (COVID-19); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002905343,0.0007215914,0.0006204371,0.0009547472,0.0003367229,0.0005417059,0.0002954742,0.000826671,0.001963363],"category_scores_gemma":[0.0001467974,0.0004209312,0.0008204601,0.0004300181,0.0005401325,0.0004803824,0.000237488,0.001891244,0.0003419355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004897917,"about_ca_system_score_gemma":0.0003200522,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001032773,"about_ca_topic_score_gemma":0.001698742,"domain_scores_codex":[0.9994569,0.00004463781,0.00006137483,0.0001757458,0.0001195025,0.0001418159],"domain_scores_gemma":[0.9993929,0.00004343108,0.0001773987,0.00004597256,0.00003701602,0.0003033006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002010162,0.0003643438,0.001083833,0.0000379573,0.00003355081,0.000191406,0.00003364219,0.00006885953,0.9952599,0.00006864402,0.00006093958,0.0007867396],"study_design_scores_gemma":[0.0002717252,0.004871673,0.05877269,0.00001801543,0.0001951096,0.001698404,0.0002871737,0.002837389,0.9287025,0.0001354585,0.002172967,0.00003702948],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955474,0.0006061117,0.001601812,0.0001121249,0.00008032356,0.00003636762,0.001234531,0.0001017756,0.0006795935],"genre_scores_gemma":[0.9903971,0.0007467268,0.002759973,0.0002264223,0.00003983988,0.0001255918,0.001978736,0.00006903042,0.00365659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001963363,"threshold_uncertainty_score":0.006568134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0523420382874244,"score_gpt":0.3451229231479734,"score_spread":0.292780884860549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}