{"id":"W3113060413","doi":"10.1093/neuonc/noaa222.732","title":"RARE-21. CANCER SPECTRUM IN GERMLINE SUFU MUTATION CARRIERS: A COLLABORATIVE PROJECT OF THE SIOPE HOST GENOME WORKING GROUP","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital","funders":"","keywords":"Germline; Medicine; Cohort; Cancer; Germline mutation; Medulloblastoma; Internal medicine; Oncology; Gastroenterology; Mutation; Pathology; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646029,0.0001827282,0.0003299861,0.0000517907,0.00008125866,0.00001007453,0.0002576149,0.0001720126,0.00001104121],"category_scores_gemma":[0.0004220137,0.0001494333,0.00007681962,0.0005759781,0.0001886949,0.000004181526,0.0002311701,0.000227236,0.000001993785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008596695,"about_ca_system_score_gemma":0.0005718654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001170508,"about_ca_topic_score_gemma":0.001427775,"domain_scores_codex":[0.9984373,0.0003565502,0.0003476992,0.000441696,0.0001334085,0.0002833714],"domain_scores_gemma":[0.9993272,0.00007852163,0.0002384204,0.0002054698,0.00009685736,0.00005353371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002921929,0.00005003745,0.007554916,0.00002724585,0.00004987925,0.0000490697,0.003080791,0.0003388485,0.9876248,0.0000231883,0.0002736299,0.0006353863],"study_design_scores_gemma":[0.002585563,0.00268781,0.01300715,0.00004134895,0.00007435067,0.00002324228,0.002471124,0.0002379154,0.7977992,0.00002848723,0.1806504,0.0003934037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929143,0.001558178,0.00008389417,0.003736111,0.0003377822,0.000706692,0.00007056619,0.00001424462,0.0005782122],"genre_scores_gemma":[0.9971241,0.0003392641,0.0001308753,0.001840644,0.000380778,0.0001138108,0.0000271904,0.0000285625,0.00001473144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1898256,"threshold_uncertainty_score":0.6093714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0266935883136722,"score_gpt":0.2919195217558639,"score_spread":0.2652259334421917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}