{"id":"W3113081454","doi":"10.1136/jitc-2020-sitc2020.0265","title":"265 Phase 1b study of avelumab + M9241 (NHS-IL12) in patients with advanced solid tumors: interim analysis results from a urothelial carcinoma (UC) dose-expansion cohort","year":2020,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Interim analysis; Interim; Avelumab; Cohort; Urothelial carcinoma; Oncology; Medicine; Internal medicine; Political science; Bladder cancer; Immunotherapy; Cancer; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003136614,0.000360353,0.0009902021,0.0002460367,0.00007656832,0.00003887249,0.0001536216,0.0001259465,0.00001870528],"category_scores_gemma":[0.0002500492,0.0002922573,0.0001538005,0.000750408,0.0002373861,0.000193985,0.00006086635,0.0002802466,0.000002300347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001065686,"about_ca_system_score_gemma":0.0003085364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002439326,"about_ca_topic_score_gemma":0.0003500867,"domain_scores_codex":[0.9971055,0.0001089705,0.001033263,0.0007649749,0.0006354692,0.0003518118],"domain_scores_gemma":[0.9983116,0.00005003638,0.0004537387,0.0005149146,0.0001571405,0.0005125636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03773657,0.003505668,0.9098084,0.0001237751,0.001894062,0.0002474857,0.00988936,0.0002405701,0.03396284,0.000001090524,0.0001825813,0.00240762],"study_design_scores_gemma":[0.04452669,0.005237709,0.930797,0.0003007904,0.0009025662,0.000004270047,0.001438563,0.0003957526,0.01597909,0.000005329116,0.00009615445,0.0003160339],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977409,0.0001554603,0.00001283404,0.0003776592,0.00009410585,0.001261387,0.000250051,0.00004686935,0.00006074279],"genre_scores_gemma":[0.9987627,0.00002574777,0.0003264971,0.0003689391,0.00008294857,0.00003122158,0.0003383622,0.0000422751,0.00002126458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02098866,"threshold_uncertainty_score":0.999953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01670594694064256,"score_gpt":0.2663233916641324,"score_spread":0.2496174447234899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}