{"id":"W3113081454","doi":"10.1136/jitc-2020-sitc2020.0265","title":"265 Phase 1b study of avelumab + M9241 (NHS-IL12) in patients with advanced solid tumors: interim analysis results from a urothelial carcinoma (UC) dose-expansion cohort","year":2020,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Interim analysis; Interim; Avelumab; Cohort; Urothelial carcinoma; Oncology; Medicine; Internal medicine; Political science; Bladder cancer; Immunotherapy; Cancer; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002538636,0.001295018,0.001547286,0.0003185652,0.0003857496,0.001045623,0.0006074451,0.0008142867,0.003354909],"category_scores_gemma":[0.0009485462,0.0004812943,0.002166241,0.0003041728,0.0005204072,0.0005182272,0.0003414166,0.002481664,0.001063169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008408265,"about_ca_system_score_gemma":0.00138332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008639062,"about_ca_topic_score_gemma":0.001668793,"domain_scores_codex":[0.9993172,0.0003450237,0.00002816182,0.00008916279,0.00007945351,0.0001410293],"domain_scores_gemma":[0.9991903,0.0001250863,0.000168171,0.0001221756,0.0000652689,0.0003289966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8128331,0.02990445,0.02049787,0.0003986838,0.002821198,0.00024585,0.0001809102,0.005994941,0.05151341,0.0002412995,0.008915768,0.0664525],"study_design_scores_gemma":[0.3418844,0.5628791,0.06225219,0.00004923086,0.002207213,0.0005742186,0.0001054167,0.004092428,0.01543354,0.0004529816,0.009993643,0.00007557538],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878512,0.001379398,0.001052522,0.0003710234,0.000110538,0.001899307,0.004826262,0.0001711251,0.002338673],"genre_scores_gemma":[0.974312,0.0008152291,0.003118678,0.0009086042,0.0001155415,0.002400352,0.01416808,0.00009467556,0.004066854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003354909,"threshold_uncertainty_score":0.01342577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01670594694064256,"score_gpt":0.2663233916641324,"score_spread":0.2496174447234899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}