{"id":"W3113117872","doi":"10.3390/polym12122983","title":"An In-Silico Pipeline for Rapid Screening of DNA Aptamers against Mycotoxins: The Case-Study of Fumonisin B1, Aflatoxin B1 and Ochratoxin A","year":2020,"lang":"en","type":"article","venue":"Polymers","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Aptamer; Microscale thermophoresis; Ochratoxin A; In silico; Aflatoxin; Systematic evolution of ligands by exponential enrichment; Ochratoxin; Oligonucleotide; Mycotoxin; Chemistry; Computational biology; Fumonisin; Fumonisin B1; DNA; Combinatorial chemistry; Biology; Biochemistry; Molecular biology; Food science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002323,0.0001790555,0.0002982833,0.00006935887,0.00007068327,0.0000110485,0.0001520692,0.00009593778,8.994811e-7],"category_scores_gemma":[0.0000784437,0.0001381826,0.0001010116,0.0002397352,0.0001852465,0.00000672402,0.00006837223,0.00008271025,4.247044e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004684425,"about_ca_system_score_gemma":0.00002743183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001275741,"about_ca_topic_score_gemma":0.0003220084,"domain_scores_codex":[0.9988371,0.000102308,0.0003825682,0.0003763327,0.0001024426,0.0001992538],"domain_scores_gemma":[0.9993101,0.00003279755,0.0002028445,0.0003120012,0.00005780639,0.00008446341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00019989,0.0001497047,0.0009746021,0.00002318066,0.00006886032,0.00001971404,0.0005192177,0.00002684363,0.9490252,0.000003827811,0.00004109655,0.04894791],"study_design_scores_gemma":[0.0009310316,0.001069819,0.0001389881,0.00002116485,0.00006985712,0.00002567942,0.01207234,0.002648469,0.982587,0.000004350058,0.0002465619,0.0001847276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968942,0.0007084822,0.001601137,0.0002590877,0.00001273425,0.0004112267,0.00004697066,0.00001640344,0.00004975009],"genre_scores_gemma":[0.9978091,0.0001500746,0.001518255,0.0003895509,0.00005980852,0.00001422802,0.00002923248,0.00002197001,0.000007856334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04876318,"threshold_uncertainty_score":0.5634921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01976943473585222,"score_gpt":0.2860752738255742,"score_spread":0.266305839089722,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}