{"id":"W3113123801","doi":"10.1080/15384047.2021.1902913","title":"Targeting EZH2-mediated methylation of histone 3 inhibits proliferation of pediatric acute monocytic leukemia cells <i>in vitro</i>","year":2021,"lang":"en","type":"article","venue":"Cancer Biology & Therapy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Weldon FOP Research Fund","keywords":"EZH2; PRC2; Cancer research; Histone H3; Histone methyltransferase; Cell culture; Methyltransferase; Cell growth; Leukemia; Biology; Myeloid leukemia; Epigenetics; Methylation; Immunology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002487903,0.0001426151,0.0002662346,0.00008611795,0.00002851238,0.000003810066,0.00009066959,0.0002589454,0.00001724464],"category_scores_gemma":[0.00004371689,0.0001397395,0.00007604893,0.0002604316,0.00006168753,0.000005324262,0.00003339729,0.00009089019,9.964806e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006604994,"about_ca_system_score_gemma":0.0003786882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000473096,"about_ca_topic_score_gemma":0.00001587984,"domain_scores_codex":[0.9987863,0.000180819,0.0004478573,0.0003241528,0.00007571327,0.0001851191],"domain_scores_gemma":[0.9991846,0.00003550756,0.0003000824,0.0001990808,0.0002451353,0.00003559651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002188509,0.00004443305,0.008147548,0.00001852361,0.00005991586,6.861426e-7,0.0001115172,0.0009380496,0.9868283,0.000009167706,0.00003403483,0.003588989],"study_design_scores_gemma":[0.001040479,0.0001773916,0.001510952,0.000005234953,0.00002577617,3.049711e-7,0.00001619536,0.000298725,0.9955595,0.000110759,0.001124772,0.0001298703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967528,0.03017937,0.001646662,0.00005694579,0.0002443298,0.0002172556,0.00007896779,0.000005710852,0.00004273036],"genre_scores_gemma":[0.9678716,0.03017328,0.0008742838,0.00009607678,0.0002197559,0.00004099278,0.0006531275,0.00001862607,0.00005228037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008731256,"threshold_uncertainty_score":0.5698412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01537197399373852,"score_gpt":0.3079283007181835,"score_spread":0.292556326724445,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}