{"id":"W3113133978","doi":"10.1093/neuonc/noaa215.946","title":"TAMI-59. METABOLIC REGULATION OF THE EPIGENOME DRIVES LETHAL INFANTILE EPENDYMOMA","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation","funders":"","keywords":"Biology; Epigenome; Epigenetics; Hypoxia (environmental); Ependymoma; Medulloblastoma; Histone methylation; Histone; Cancer research; Cell biology; Genetics; DNA methylation; Chemistry; Pathology; Medicine; Gene expression; Oxygen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008134026,0.0002856702,0.0002149175,0.0001855089,0.0002086032,0.0002056869,0.0002175998,0.000346069,0.003840513],"category_scores_gemma":[0.0001628662,0.0001207641,0.0002938221,0.0001421648,0.0002082334,0.00008961035,0.0002855964,0.0005742189,0.0009700935],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002688481,"about_ca_system_score_gemma":0.0001638172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000614982,"about_ca_topic_score_gemma":0.001055203,"domain_scores_codex":[0.999913,0.00001053279,0.000007996147,0.00002561575,0.00001690521,0.00002594191],"domain_scores_gemma":[0.9999055,0.00001494752,0.00002856832,0.000008090174,0.000005426106,0.0000374073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000353268,0.0001017708,0.00243161,0.00008887431,0.00001893987,0.004307387,0.00005477601,0.0002406399,0.9849338,0.0006937061,0.0005177421,0.006257572],"study_design_scores_gemma":[0.0001406718,0.001815712,0.08940025,0.00007117746,0.0001446588,0.0171128,0.000360394,0.007537361,0.8486927,0.0009989553,0.03368634,0.0000389995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879539,0.001121114,0.004222453,0.000339192,0.0001470756,0.00006401952,0.001477334,0.0002850558,0.004389836],"genre_scores_gemma":[0.994313,0.0004234368,0.001035124,0.0001493866,0.00001392947,0.00004449845,0.0007033735,0.00005463547,0.003262626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003840513,"threshold_uncertainty_score":0.01284778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01314354954261283,"score_gpt":0.2558142341550323,"score_spread":0.2426706846124195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}