{"id":"W3113175873","doi":"10.3747/co.27.7103","title":"Management of Hepatocellular Carcinoma after Progression on First-Line Systemic Treatment: Defining the Optimal Sequencing Strategy in Second Line and Beyond","year":2020,"lang":"en","type":"review","venue":"Current Oncology","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Sorafenib; Lenvatinib; Regorafenib; Ramucirumab; Medicine; Cabozantinib; Hepatocellular carcinoma; Bevacizumab; Atezolizumab; Oncology; Internal medicine; Systemic therapy; Nivolumab; Overall survival; Immunotherapy; Cancer; Chemotherapy; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007760848,0.0005057404,0.001403239,0.001160821,0.0001820285,0.0008344933,0.0006462378,0.0008510461,0.00248776],"category_scores_gemma":[0.001529357,0.0001465212,0.0008547634,0.0009021375,0.0002612023,0.0009800909,0.0004013483,0.001283802,0.0007982092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006407645,"about_ca_system_score_gemma":0.001320331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001236433,"about_ca_topic_score_gemma":0.003008378,"domain_scores_codex":[0.9997696,0.00007212725,0.00005193873,0.0000321576,0.00005422093,0.00001990416],"domain_scores_gemma":[0.9995524,0.0002511911,0.00007603293,0.000007652508,0.00009411135,0.00001852148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001108826,0.00004231953,0.0002697295,0.03545199,0.0002469471,0.0001572961,0.00005415166,0.0004482212,0.0004818501,0.001769334,0.02019845,0.9407687],"study_design_scores_gemma":[0.0001549938,0.000299487,0.003324261,0.06618444,0.001494224,0.002748485,0.0002127364,0.0005580091,0.0005376313,0.005256233,0.9191782,0.0000512591],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001215132,0.9985695,0.0001082875,0.0006371783,0.0001354522,0.000005732854,0.00001604322,0.000003659696,0.0004027296],"genre_scores_gemma":[0.001095969,0.9979349,0.0002475529,0.0003765141,0.0001363434,0.000009923633,0.00003553166,0.000001254151,0.000161928],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00248776,"threshold_uncertainty_score":0.008322358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1781272507176914,"score_gpt":0.3761642650941853,"score_spread":0.1980370143764939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}