{"id":"W3113178349","doi":"10.1093/neuonc/noaa215.463","title":"IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Chimeric antigen receptor; Antigen; Epidermal growth factor receptor; Cancer research; Glioma; Tumor antigen; Brain tumor; Immunotherapy; Receptor; Priming (agriculture); Biology; Immunology; Medicine; Immune system; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001114411,0.0002851583,0.0001990656,0.0001295244,0.00009211661,0.0002931754,0.0002140514,0.0002244971,0.0009711643],"category_scores_gemma":[0.00005370155,0.00008413625,0.0001374777,0.0000757134,0.000124186,0.00018593,0.0001861342,0.0004010667,0.0002746282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004510266,"about_ca_system_score_gemma":0.0002410546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005992476,"about_ca_topic_score_gemma":0.0009613444,"domain_scores_codex":[0.9999059,0.00001253132,0.000004581892,0.00001897494,0.00002426922,0.00003366567],"domain_scores_gemma":[0.9999728,0.000003266751,0.000008419645,0.000002974967,0.000005893948,0.000006627009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001032265,0.00007103524,0.0001235345,0.00006016896,0.000006141285,0.00004144615,0.00001757181,0.0007004527,0.9891835,0.0007062309,0.0001490229,0.008837739],"study_design_scores_gemma":[0.00003730436,0.001112421,0.0006679135,0.000006018431,0.00003087592,0.0002195106,0.00001258673,0.005969495,0.9855357,0.0001256473,0.006277187,0.000005209804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750543,0.003005706,0.01797443,0.0001943833,0.00005440622,0.0001558034,0.0001399025,0.0002123083,0.003208694],"genre_scores_gemma":[0.9920402,0.000593755,0.0051338,0.00006904643,0.00001034657,0.00005514262,0.00009275888,0.00001357269,0.001991523],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009711643,"threshold_uncertainty_score":0.003272474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1287880385166578,"score_gpt":0.3577282219212788,"score_spread":0.2289401834046211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}