{"id":"W3113282562","doi":"10.1002/cpch.88","title":"Methods to Validate Binding and Kinetics of “Proximity‐Inducing” Covalent Immune‐Recruiting Molecules","year":2020,"lang":"en","type":"article","venue":"Current Protocols in Chemical Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Prostate Cancer Canada","keywords":"Covalent bond; Chemistry; Surface plasmon resonance; Immune system; Antibody; Flow cytometry; Receptor–ligand kinetics; Biophysics; Click chemistry; Mass cytometry; Kinetics; Biochemistry; Molecular biology; Nanotechnology; Combinatorial chemistry; Biology; Materials science; Immunology; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003320311,0.001365223,0.0006670039,0.0008717062,0.0006977202,0.0007069895,0.001524584,0.001245235,0.001994751],"category_scores_gemma":[0.00439611,0.0007226266,0.0005491281,0.0008609855,0.0008013902,0.0007504466,0.0005879853,0.002097512,0.001383419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001560311,"about_ca_system_score_gemma":0.001017969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001515249,"about_ca_topic_score_gemma":0.001425861,"domain_scores_codex":[0.9962355,0.0006348941,0.0002764284,0.0007923782,0.001748048,0.0003127014],"domain_scores_gemma":[0.9968886,0.001014321,0.0006632825,0.0005871165,0.0007093298,0.0001374344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005924053,0.0001487681,0.0003482277,0.0001301041,0.00001391586,0.00001936551,0.00005951903,0.0005496962,0.9935192,0.0004665258,0.0001293904,0.004556151],"study_design_scores_gemma":[0.000009462871,0.0002687247,0.0006411839,0.000006457956,0.000009996947,0.00003955495,0.00001553503,0.00447017,0.9933727,0.00009235201,0.001063368,0.0000106641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3722885,0.002480518,0.6129444,0.0003341444,0.0002445345,0.002186151,0.001262761,0.00193805,0.006321009],"genre_scores_gemma":[0.5727261,0.003429705,0.4109358,0.000522547,0.000122148,0.005052253,0.001630766,0.0002710015,0.00530965],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003320311,"threshold_uncertainty_score":0.01755965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1962104997411785,"score_gpt":0.4964013411968491,"score_spread":0.3001908414556706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}