{"id":"W3113287358","doi":"10.1093/neuonc/noaa215.693","title":"PATH-11. PROGNOSTIC SIGNIFICANCE OF EPIGENETIC SUBTYPES AND CpGs ASSOCIATED WITH PROGRESSION TO G-CIMP LOW IN THE EORTC RANDOMIZED PHASE III INTERGROUP CATNON","year":2020,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Epigenetics; IDH1; Glioma; Oncology; Medicine; Internal medicine; Methylation; Bioinformatics; Cancer research; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005584682,0.00048828,0.0006883892,0.0001474212,0.0002076626,0.0007021062,0.0005225898,0.0007964089,0.002514211],"category_scores_gemma":[0.002611291,0.0002612112,0.001087696,0.0002359897,0.0006750372,0.0004501512,0.0004014653,0.0009936516,0.0002430808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005756513,"about_ca_system_score_gemma":0.001038384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005393904,"about_ca_topic_score_gemma":0.00154983,"domain_scores_codex":[0.9981585,0.001365138,0.00007734708,0.0002138205,0.0001018987,0.0000832713],"domain_scores_gemma":[0.9977775,0.0008490826,0.0005548346,0.0003298818,0.0001329341,0.0003556723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9073106,0.002515754,0.05939019,0.0004905922,0.002009833,0.0000616963,0.0000789168,0.001511385,0.008612961,0.0003264018,0.002085058,0.01560654],"study_design_scores_gemma":[0.5620632,0.2201222,0.1871702,0.0001462604,0.005016934,0.0002653096,0.0001591265,0.009646016,0.007936133,0.001814208,0.005591835,0.00006858653],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948674,0.0008328234,0.0006122198,0.0003347625,0.00009555171,0.0008136423,0.001546256,0.0000319239,0.0008653264],"genre_scores_gemma":[0.9923708,0.0002059048,0.001065218,0.0004505288,0.00005733211,0.001838866,0.002639845,0.00001930125,0.001352162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005584682,"threshold_uncertainty_score":0.029535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662181217987583,"score_gpt":0.3010149343198744,"score_spread":0.2843931221399985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}