{"id":"W3113323193","doi":"10.3390/cancers12123688","title":"Lamin A/C: Function in Normal and Tumor Cells","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canada Research Chairs; University of Manitoba","keywords":"Lamin; Genome instability; Biology; DNA repair; Cancer research; Cancer; Chromosome instability; DNA damage; Telomere; Gene; Cell biology; Nuclear lamina; Cell; Genetics; Bioinformatics; DNA; Chromosome; Nuclear protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003037485,0.0001462868,0.0002904941,0.0000319428,0.00001867167,0.00001113576,0.00005449696,0.0001458102,0.00002553321],"category_scores_gemma":[0.00000692209,0.0001315872,0.00007483769,0.00007676087,0.00002678365,0.000001578571,0.00003993717,0.0001340442,0.00001308651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009276871,"about_ca_system_score_gemma":0.0002241115,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000238091,"about_ca_topic_score_gemma":0.00003994711,"domain_scores_codex":[0.9994224,0.00002729411,0.000133555,0.0002671178,0.00004003202,0.0001096118],"domain_scores_gemma":[0.9997646,0.000003118581,0.00006854957,0.0001107268,0.000008219347,0.00004478676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003201593,0.000001182372,0.000004832817,0.001448045,0.00004238781,0.000008396608,0.000009448643,0.000005170788,0.0005121489,0.00001377856,0.006476109,0.9914465],"study_design_scores_gemma":[0.0001069418,0.0001105153,0.00000782088,0.0002274589,0.00007816969,0.00001173065,0.000009408533,0.000003873461,0.00006846961,0.000003964708,0.9992355,0.0001361927],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002061048,0.9983184,0.00002120049,0.000005481252,0.0005026779,0.000158107,0.00002494005,0.000005850993,0.0007572048],"genre_scores_gemma":[0.0002435242,0.9987287,0.00003347757,0.0001840919,0.0004353711,0.00001782742,0.0001236166,0.00002481848,0.0002085676],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9927593,"threshold_uncertainty_score":0.5365972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009888089241230868,"score_gpt":0.2418315400022225,"score_spread":0.2319434507609916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}