{"id":"W3113323193","doi":"10.3390/cancers12123688","title":"Lamin A/C: Function in Normal and Tumor Cells","year":2020,"lang":"en","type":"review","venue":"Cancers","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canada Research Chairs; University of Manitoba","keywords":"Lamin; Genome instability; Biology; DNA repair; Cancer research; Cancer; Chromosome instability; DNA damage; Telomere; Gene; Cell biology; Nuclear lamina; Cell; Genetics; Bioinformatics; DNA; Chromosome; Nuclear protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002829641,0.0007346573,0.0007648297,0.001611838,0.0003535473,0.0008668297,0.000570245,0.0009029158,0.002204972],"category_scores_gemma":[0.0003504042,0.000204344,0.0003117881,0.001304166,0.0004475039,0.00100767,0.0006110452,0.001140012,0.001698054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008011704,"about_ca_system_score_gemma":0.001007676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001719123,"about_ca_topic_score_gemma":0.001675022,"domain_scores_codex":[0.9998605,0.00002023598,0.00002122428,0.00003157598,0.00005036174,0.00001606143],"domain_scores_gemma":[0.9999108,0.00002892061,0.00001566207,0.00000389924,0.00002637409,0.00001433169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001039747,0.00003508407,0.0002028568,0.01447965,0.00005902457,0.0002966237,0.0001092522,0.0003906893,0.008096405,0.006120332,0.02655783,0.9435483],"study_design_scores_gemma":[0.000005171005,0.00004868007,0.0005195121,0.00187249,0.00003904465,0.001197847,0.00004667269,0.00003581835,0.001028108,0.001454758,0.9937387,0.0000132522],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001219001,0.9984502,0.00009753553,0.0001281657,0.0001431308,0.000002168707,0.00001652639,0.000005875137,0.001034532],"genre_scores_gemma":[0.0008617698,0.9978414,0.0001424366,0.0001050594,0.0001007215,0.000004451615,0.00003563121,0.000001525228,0.00090704],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002204972,"threshold_uncertainty_score":0.007376432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009888089241230868,"score_gpt":0.2418315400022225,"score_spread":0.2319434507609916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}