{"id":"W3113403290","doi":"10.3390/life11010001","title":"The ER Stress/UPR Axis in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis","year":2020,"lang":"en","type":"review","venue":"Life","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; CancerCare Manitoba; Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute","keywords":"Unfolded protein response; Endoplasmic reticulum; Pulmonary fibrosis; Medicine; COPD; Idiopathic pulmonary fibrosis; Secretion; Disease; Homeostasis; Immunology; Bioinformatics; Fibrosis; Cancer research; Lung; Biology; Cell biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009420352,0.0005053632,0.0007482226,0.00004816707,0.000165142,0.00007857673,0.0004098606,0.0002969624,0.00001106545],"category_scores_gemma":[0.0002864256,0.0003577646,0.0003815758,0.0001666111,0.0002464778,0.000006648672,0.0004526821,0.0003657347,0.00001748061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006751216,"about_ca_system_score_gemma":0.0008678148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002335393,"about_ca_topic_score_gemma":0.00001463731,"domain_scores_codex":[0.9977638,0.0002612773,0.0005177523,0.0008309737,0.0002082771,0.000417983],"domain_scores_gemma":[0.9985132,0.00006510927,0.0002325964,0.000628834,0.00003231745,0.0005279225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002566865,0.0001278189,0.001470816,0.01799662,0.0003055838,0.0007488951,0.00002380654,0.00001813314,0.0001306725,0.0002167935,0.0006376911,0.9780665],"study_design_scores_gemma":[0.0001809829,0.00007537278,0.001410672,0.003298556,0.0004402193,0.00003309884,0.00004650919,0.00009671975,0.00002225065,0.00009929779,0.9937191,0.0005772095],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008540835,0.9971878,0.000004241192,0.000126152,0.0001612175,0.0006124772,0.0005831936,0.00001538,0.0004554447],"genre_scores_gemma":[0.02415292,0.9738775,0.000009593506,0.00006705358,0.0007768204,0.0003201815,0.0005244729,0.00006756476,0.0002039012],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9930814,"threshold_uncertainty_score":0.9998874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223282794069283,"score_gpt":0.2630582920967255,"score_spread":0.2508254641560327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}