{"id":"W3113403290","doi":"10.3390/life11010001","title":"The ER Stress/UPR Axis in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis","year":2020,"lang":"en","type":"review","venue":"Life","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital; CancerCare Manitoba; Research Institute in Oncology and Hematology; Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Heart, Lung, and Blood Institute","keywords":"Unfolded protein response; Endoplasmic reticulum; Pulmonary fibrosis; Medicine; COPD; Idiopathic pulmonary fibrosis; Secretion; Disease; Homeostasis; Immunology; Bioinformatics; Fibrosis; Cancer research; Lung; Biology; Cell biology; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002745813,0.0006240716,0.000890161,0.00174104,0.0002724363,0.0006655175,0.0004918046,0.0008115043,0.003928527],"category_scores_gemma":[0.0003446568,0.0001861382,0.0004023481,0.001705929,0.0002641323,0.00076195,0.0005884714,0.001374134,0.00184323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004428466,"about_ca_system_score_gemma":0.0008070778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008604627,"about_ca_topic_score_gemma":0.001810759,"domain_scores_codex":[0.9998935,0.00001804265,0.00001688811,0.00001957843,0.00003927105,0.00001265606],"domain_scores_gemma":[0.9998689,0.00004894679,0.0000193924,0.000003786171,0.00004230829,0.0000166137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009423153,0.00005909649,0.0002106408,0.01458716,0.00007913854,0.0002873295,0.00006105994,0.0002999273,0.002382979,0.00275703,0.03003471,0.9491466],"study_design_scores_gemma":[0.00001328025,0.0001071954,0.001259938,0.00307746,0.00009691532,0.001787851,0.00005144116,0.00008809349,0.0004738686,0.00152312,0.9915053,0.00001556952],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001273067,0.9983204,0.00009511241,0.0002188776,0.0002235529,0.000003775606,0.00001762916,0.000007785346,0.0009854449],"genre_scores_gemma":[0.0006941835,0.9980651,0.0001309324,0.0001565201,0.0001568764,0.000004891479,0.00003717441,0.000001250775,0.0007531479],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003928527,"threshold_uncertainty_score":0.01314217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01223282794069283,"score_gpt":0.2630582920967255,"score_spread":0.2508254641560327,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}