{"id":"W3113573257","doi":"10.1111/petr.13959","title":"Age and sex determine conversion from immediate‐release to extended‐release tacrolimus in a multi‐center cohort of Canadian pediatric renal transplant recipients","year":2020,"lang":"en","type":"article","venue":"Pediatric Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Research Manitoba; McGill University; The Metabolomics Innovation Centre; McGill University Health Centre; Montreal Children's Hospital; University of Manitoba; George & Fay Yee Centre for Healthcare Innovation; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Tacrolimus; Proportional hazards model; Cohort; Internal medicine; Observational study; Prospective cohort study; Transplantation; Cohort study; Renal transplant; Trough level","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001035912,0.0003281469,0.0005328804,0.0009470971,0.00006274974,0.00001931953,0.000108274,0.0001665611,0.00009172718],"category_scores_gemma":[0.00001832691,0.0003088281,0.0001215376,0.0008848014,0.00002753143,0.0001574374,0.000006890986,0.0002296989,0.00003909164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008266635,"about_ca_system_score_gemma":0.0001716823,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02152874,"about_ca_topic_score_gemma":0.007641868,"domain_scores_codex":[0.9978006,0.00008246787,0.0006876633,0.000580732,0.0004217094,0.0004268315],"domain_scores_gemma":[0.9985182,0.0001344641,0.0001345084,0.0001586405,0.00005661557,0.0009975206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001484947,0.0002741148,0.9889487,0.0004801943,0.00005829976,0.004127512,0.003573812,0.00006927799,0.0004771045,0.000001832491,0.00002513398,0.0004790965],"study_design_scores_gemma":[0.01213953,0.0003651533,0.9840361,0.0001151146,0.00118583,0.00007805695,0.0000226759,0.000584412,0.001164457,0.000003209579,0.00003575438,0.0002697067],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951657,0.0002574821,0.0008701311,0.0003684228,0.0001387605,0.0009852044,0.002090544,0.00003987706,0.00008390172],"genre_scores_gemma":[0.9796607,0.01590128,0.001493729,0.000592378,0.0001844568,0.0000444695,0.002052032,0.0000383343,0.00003263286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0156438,"threshold_uncertainty_score":0.9999364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02154400173402372,"score_gpt":0.2553418285274406,"score_spread":0.2337978267934169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}