{"id":"W3113574244","doi":"10.1002/iid3.383","title":"Separate signaling events control TCR downregulation and T cell activation in primary human T cells","year":2020,"lang":"en","type":"article","venue":"Immunity Inflammation and Disease","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Institute of Infection and Immunity; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Downregulation and upregulation; T-cell receptor; Jurkat cells; FYN; Cell biology; T cell; Biology; CD3; Tyrosine kinase; Signal transduction; Tyrosine-protein kinase CSK; CD8; Cancer research; Immunology; SH2 domain; Antigen; Immune system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001727773,0.0001700696,0.0002171681,0.0001053425,0.000267942,0.00002809941,0.0000893131,0.0001509212,0.0001681846],"category_scores_gemma":[0.00004750644,0.0001713972,0.00003884741,0.0001073921,0.0001085301,0.00029069,0.00006446772,0.0002529972,0.00007645287],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003154551,"about_ca_system_score_gemma":0.00005453888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000567251,"about_ca_topic_score_gemma":0.000003105548,"domain_scores_codex":[0.9988438,0.0003596472,0.0003427483,0.0002167817,0.00003780063,0.000199196],"domain_scores_gemma":[0.9994623,0.00009929492,0.0001672252,0.0001442977,0.00004866135,0.00007820847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005323212,0.00007958295,0.003726165,0.00009090349,0.00002489421,0.000001788735,0.0007517174,0.0001661321,0.9932052,0.0001746955,0.00008408815,0.001162485],"study_design_scores_gemma":[0.01065424,0.0002050023,0.1386032,0.00007844311,0.0001053403,0.000002381181,0.0004908887,0.0004398587,0.8458213,0.00111888,0.001998022,0.0004824666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974816,0.0004908823,0.0003160199,0.0007922596,0.00006155506,0.0003835036,0.00001777054,0.00006046209,0.0003958882],"genre_scores_gemma":[0.9988272,0.00004430084,0.00001572207,0.0004060646,0.00002565893,0.00002098293,0.0004141615,0.00001057568,0.0002352883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.147384,"threshold_uncertainty_score":0.6989377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140761221353848,"score_gpt":0.2221430515075304,"score_spread":0.2107354392939919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}