{"id":"W3113574244","doi":"10.1002/iid3.383","title":"Separate signaling events control TCR downregulation and T cell activation in primary human T cells","year":2020,"lang":"en","type":"article","venue":"Immunity Inflammation and Disease","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Institute of Infection and Immunity; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Downregulation and upregulation; T-cell receptor; Jurkat cells; FYN; Cell biology; T cell; Biology; CD3; Tyrosine kinase; Signal transduction; Tyrosine-protein kinase CSK; CD8; Cancer research; Immunology; SH2 domain; Antigen; Immune system; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001636269,0.000398429,0.0004150382,0.0002506908,0.0002018944,0.0006396152,0.0001555549,0.0003690068,0.002379637],"category_scores_gemma":[0.0001793495,0.0001912487,0.0004313563,0.0002278201,0.0002027229,0.0002243182,0.0002384239,0.0006573714,0.001164308],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004426856,"about_ca_system_score_gemma":0.000311537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003640462,"about_ca_topic_score_gemma":0.0005067364,"domain_scores_codex":[0.9995781,0.00004513751,0.0000440211,0.0001131519,0.0001011658,0.0001185762],"domain_scores_gemma":[0.999867,0.00003073555,0.00003297264,0.00001729761,0.00002432073,0.00002760493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001362642,0.00002011967,0.0002925473,0.00004209726,0.000004152739,0.00006291346,0.00001529284,0.00002985883,0.9983281,0.00007213978,0.00004678712,0.0009496541],"study_design_scores_gemma":[0.0000276477,0.0001924739,0.01375953,0.00001094457,0.00003333378,0.0006089291,0.0000362453,0.0005405989,0.9822943,0.00008029868,0.00240876,0.000006791443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708611,0.007876478,0.01470519,0.0001325444,0.00008719922,0.0001509902,0.0014489,0.0003684953,0.004369176],"genre_scores_gemma":[0.9912279,0.001822814,0.003262129,0.00007357319,0.00002897811,0.000146327,0.001254864,0.00003495921,0.002148464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002379637,"threshold_uncertainty_score":0.007960618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01140761221353848,"score_gpt":0.2221430515075304,"score_spread":0.2107354392939919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}