{"id":"W3113626698","doi":"10.1016/j.omtm.2020.12.012","title":"AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stichting Blindenhulp; Rotterdamse Stichting Blindenbelangen; Landelijke Stichting voor Blinden en Slechtzienden; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; ZonMw; Stichting MaculaFonds; Stichting Blinden-Penning; Stichting Steunfonds Uitzicht; Foundation Fighting Blindness","keywords":"Retinitis pigmentosa; Biology; Retinal degeneration; Retinal; Retina; Electroretinography; Cell biology; Photoreceptor cell; Rhodopsin; Molecular biology; Biochemistry; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003661114,0.0007620048,0.0003351977,0.001215948,0.0003245197,0.0004989991,0.000482477,0.001125709,0.003517331],"category_scores_gemma":[0.0001243398,0.0003550332,0.0004078044,0.0002834444,0.000558971,0.0004535892,0.0002204108,0.00149454,0.0008754528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004600036,"about_ca_system_score_gemma":0.000398132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001229598,"about_ca_topic_score_gemma":0.001826964,"domain_scores_codex":[0.9996092,0.00004940143,0.00003012635,0.00009570864,0.0001342902,0.00008129392],"domain_scores_gemma":[0.9997588,0.00001480612,0.00008229643,0.00002787698,0.0000212964,0.00009489783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003195304,0.0001416872,0.00008446487,0.00004012645,0.000007767725,0.00008452844,0.00001586329,0.00004896668,0.9970436,0.000326183,0.0001853064,0.001702068],"study_design_scores_gemma":[0.0001478,0.0009807333,0.002379906,0.00002710785,0.00003731149,0.0006118153,0.0000419775,0.001110836,0.9896795,0.0001294387,0.004842603,0.00001111333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697784,0.003876249,0.01331742,0.0008749355,0.000455713,0.0002092159,0.001975345,0.001206397,0.008306351],"genre_scores_gemma":[0.9576069,0.001910989,0.00846685,0.0001916458,0.00003867295,0.0001954755,0.00113301,0.0001725457,0.03028396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003517331,"threshold_uncertainty_score":0.01176661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09446519797469939,"score_gpt":0.4295733912635136,"score_spread":0.3351081932888142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}