{"id":"W3113626698","doi":"10.1016/j.omtm.2020.12.012","title":"AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Stichting Blindenhulp; Rotterdamse Stichting Blindenbelangen; Landelijke Stichting voor Blinden en Slechtzienden; Algemene Nederlandse Vereniging ter voorkoming van Blindheid; ZonMw; Stichting MaculaFonds; Stichting Blinden-Penning; Stichting Steunfonds Uitzicht; Foundation Fighting Blindness","keywords":"Retinitis pigmentosa; Biology; Retinal degeneration; Retinal; Retina; Electroretinography; Cell biology; Photoreceptor cell; Rhodopsin; Molecular biology; Biochemistry; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002596474,0.0005121383,0.0005957015,0.0001103792,0.0001333147,0.00009858647,0.0006495927,0.0005225018,0.0000358338],"category_scores_gemma":[0.0005508818,0.0004901381,0.0002328424,0.0003638078,0.000162895,0.00002526864,0.0003385563,0.0004955993,0.00002579017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004356384,"about_ca_system_score_gemma":0.000560682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004705765,"about_ca_topic_score_gemma":0.000009972247,"domain_scores_codex":[0.9948992,0.001323626,0.00129626,0.001370952,0.0004581391,0.0006518876],"domain_scores_gemma":[0.9984156,0.00005301118,0.0002671061,0.0006110225,0.0001604548,0.0004928262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001136645,0.0005824731,0.006483863,0.00004219457,0.0001317244,0.00005417191,0.000657863,0.0007621381,0.7695314,0.00005589222,0.000221488,0.2203401],"study_design_scores_gemma":[0.004213234,0.001240931,0.00559658,0.00006073934,0.000009024645,0.000002627002,0.0001103646,0.003390975,0.9495273,0.000538677,0.03417432,0.001135196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.8333372,0.000540319,0.1633346,0.001003934,0.0001294626,0.0009567025,0.000004763232,0.00005572194,0.0006372679],"genre_scores_gemma":[0.4268341,0.001645604,0.5609628,0.009498009,0.00009831512,0.0002416815,0.0002727629,0.0001171842,0.0003295082],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.4065031,"threshold_uncertainty_score":0.999755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09446519797469939,"score_gpt":0.4295733912635136,"score_spread":0.3351081932888142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}