{"id":"W3113754461","doi":"10.1038/s41588-021-00923-x","title":"Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation","year":2021,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":539,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Public Health Ontario; University of Toronto","funders":"Economic and Social Research Council; Medical Research Council; Directorate for Biological Sciences; Nederlandse Federatie van Universitair Medische Centra; Biotechnology and Biological Sciences Research Council; ZonMw; Österreichischen Akademie der Wissenschaften; Wellcome Trust; Agence Nationale de la Recherche; Research Councils UK; Motor Neurone Disease Association; National Institute for Health and Care Research; University of Bristol; Joint Programming Initiative A healthy diet for a healthy life; Cancer Research UK; British Heart Foundation; Royal Society; Wellcome","keywords":"Biology; DNA methylation; Genetics; Phenotype; Computational biology; Evolutionary biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735575,0.0002360667,0.0002520185,0.0008710548,0.0002562377,0.0005536653,0.0003724516,0.0003200767,0.004350112],"category_scores_gemma":[0.0002285635,0.0002483257,0.0002718051,0.0005367131,0.0003280228,0.0004200505,0.0005250358,0.0007585819,0.0007500223],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003750054,"about_ca_system_score_gemma":0.0002212501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001047044,"about_ca_topic_score_gemma":0.002243064,"domain_scores_codex":[0.9998947,0.00001197673,0.000004834489,0.00002999572,0.00003846391,0.00001990538],"domain_scores_gemma":[0.9998142,0.0000426214,0.00003045668,0.00004983488,0.00002270338,0.00004019251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00009065986,0.000006986506,0.000735346,0.00002951553,0.00001259125,0.0001433964,0.00002073671,0.0006327024,0.9875758,0.002888162,0.0003397578,0.007524384],"study_design_scores_gemma":[0.0000227129,0.0001265319,0.04600546,0.00001256983,0.00008306166,0.001601846,0.00008683859,0.004591414,0.9171828,0.006357688,0.02388903,0.00003999788],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8169011,0.004507545,0.1388689,0.001307282,0.0002747242,0.000046991,0.008846808,0.0028841,0.02636249],"genre_scores_gemma":[0.9582061,0.00253815,0.02330111,0.0002545091,0.00005322853,0.00003903735,0.002184286,0.0004329961,0.01299048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004350112,"threshold_uncertainty_score":0.01455259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005549023439395979,"score_gpt":0.2485398492865872,"score_spread":0.2429908258471912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}