{"id":"W3113754461","doi":"10.1038/s41588-021-00923-x","title":"Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation","year":2021,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":539,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Public Health Ontario; University of Toronto","funders":"Economic and Social Research Council; Medical Research Council; Directorate for Biological Sciences; Nederlandse Federatie van Universitair Medische Centra; Biotechnology and Biological Sciences Research Council; ZonMw; Österreichischen Akademie der Wissenschaften; Wellcome Trust; Agence Nationale de la Recherche; Research Councils UK; Motor Neurone Disease Association; National Institute for Health and Care Research; University of Bristol; Joint Programming Initiative A healthy diet for a healthy life; Cancer Research UK; British Heart Foundation; Royal Society; Wellcome","keywords":"Biology; DNA methylation; Genetics; Phenotype; Computational biology; Evolutionary biology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006286884,0.0001978506,0.000202561,0.00005643028,0.00006209664,0.0000256416,0.0001308295,0.0005323765,0.000008352191],"category_scores_gemma":[0.00009802896,0.0001982281,0.00006235155,0.0001132779,0.00004624294,0.000002903786,0.00009357196,0.0001975211,0.000003487914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001272815,"about_ca_system_score_gemma":0.0000786924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006061852,"about_ca_topic_score_gemma":0.00006401503,"domain_scores_codex":[0.9987234,0.0001609917,0.0002547547,0.0005070047,0.0001933343,0.0001604378],"domain_scores_gemma":[0.9990149,0.00005420287,0.0001250369,0.0005240104,0.0001725218,0.0001093429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004424607,0.00005609022,0.01009024,0.00002525133,0.00005436993,0.00000450863,0.00008735026,0.0002980474,0.9643297,0.00006243213,0.00002987075,0.02491787],"study_design_scores_gemma":[0.0004039844,0.0003162026,0.2949513,0.00001230251,0.00004556548,9.452633e-7,0.0000121719,0.0001637246,0.697785,0.002014138,0.004139456,0.000155211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9360802,0.06224397,0.000871385,0.00003878476,0.0003110004,0.0001547824,0.00002419924,0.000007817624,0.0002678111],"genre_scores_gemma":[0.9891829,0.003855653,0.005781619,0.000225157,0.0004994351,0.000006122624,0.000361537,0.00003597252,0.00005152831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2848611,"threshold_uncertainty_score":0.8083507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005549023439395979,"score_gpt":0.2485398492865872,"score_spread":0.2429908258471912,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}