{"id":"W3113903917","doi":"10.1038/s41467-020-20183-3","title":"An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris","year":2020,"lang":"en","type":"article","venue":"Nature Communications","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Center for Advancing Translational Sciences; Canadian Institutes of Health Research; Centers for Disease Control and Prevention; U.S. Department of Health and Human Services; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Broad Institute; National Institute of General Medical Sciences; Canadian Institute for Advanced Research","keywords":"Candida auris; Fluconazole; Efflux; Microbiology; Azole; Pathogen; Fungal pathogen; Biology; Candida albicans; Corpus albicans; Virulence; Antifungal; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009001279,0.0003185576,0.000230641,0.0002173869,0.0001023528,0.0002731757,0.0002157002,0.0001953686,0.001058589],"category_scores_gemma":[0.00006797121,0.00006792657,0.0001447918,0.0001307844,0.0001097306,0.00008892239,0.0001366166,0.0003275656,0.0001639852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001828916,"about_ca_system_score_gemma":0.0001798653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00105887,"about_ca_topic_score_gemma":0.00251877,"domain_scores_codex":[0.9998927,0.00002012903,0.000007762624,0.00001228116,0.00003474444,0.00003244436],"domain_scores_gemma":[0.9999496,0.00000943136,0.00001309663,0.000003875155,0.000007124666,0.00001689774],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002964295,0.0001537696,0.0002653373,0.00004638928,0.000007965987,0.0000605451,0.000009477597,0.000153185,0.9948123,0.00005534149,0.0001237512,0.004015504],"study_design_scores_gemma":[0.00008233254,0.003687451,0.0120524,0.00001178607,0.00003808687,0.0003819284,0.00003346674,0.001661744,0.9791379,0.00004429025,0.002859236,0.000009421687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948737,0.001261835,0.0006140913,0.000107753,0.00002621219,0.00002878299,0.0002977591,0.00008849466,0.002701275],"genre_scores_gemma":[0.9962369,0.0009477241,0.0007619829,0.00005878212,0.00001169031,0.00001951209,0.0004068417,0.000008473085,0.001548079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105887,"threshold_uncertainty_score":0.003541291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02038064154639831,"score_gpt":0.3103674624677474,"score_spread":0.2899868209213491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}