{"id":"W3113907347","doi":"10.1186/s13024-021-00432-9","title":"Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy","year":2021,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast; China Scholarship Council; Fight for Sight UK","keywords":"CX3CR1; Retinal; Neurology; Neuroscience; Molecular medicine; SOCS3; Medicine; Biology; Ophthalmology; Cell biology; Internal medicine; Receptor; Genetics; Cell; Signal transduction; Cell cycle","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003194548,0.0001758122,0.0002498089,0.0003253918,0.00005801057,0.00004013843,0.0001145349,0.00008098585,0.00001512803],"category_scores_gemma":[0.0002348118,0.0002066036,0.00003686536,0.0005685384,0.00004730934,0.0001302221,0.00008521574,0.0001666711,0.000004273867],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003403426,"about_ca_system_score_gemma":0.0001359208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006745552,"about_ca_topic_score_gemma":0.0001481369,"domain_scores_codex":[0.997361,0.0005921668,0.000841714,0.0005836331,0.0004221936,0.0001992815],"domain_scores_gemma":[0.9992833,0.00005354653,0.0002387613,0.0002702098,0.0001000859,0.00005416459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005152965,0.0001328395,0.00006828096,0.00004087088,9.653849e-7,0.0002769952,0.0004506409,0.003341642,0.9925861,0.001908485,0.000005070532,0.001136603],"study_design_scores_gemma":[0.0008519721,0.0000662953,0.001010521,0.00002962589,0.000004830649,0.00003054518,0.00002427324,0.003414464,0.9942172,0.0001442321,0.00005643399,0.000149592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932991,0.00004219795,0.00589384,0.0001523973,0.0001704216,0.0002830604,0.000008963411,0.0000222556,0.0001278102],"genre_scores_gemma":[0.9960305,0.00007025497,0.00339045,0.0003477751,0.0000125796,0.00001923426,0.00002298535,0.00002496289,0.00008126867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002731435,"threshold_uncertainty_score":0.842505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01998556889932403,"score_gpt":0.2389395696832527,"score_spread":0.2189540007839286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}