{"id":"W3114055015","doi":"10.1002/anie.202014162","title":"Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Alberta","keywords":"Ribonucleoprotein; CRISPR; Cas9; HeLa; Corona (planetary geology); HEK 293 cells; Cell biology; RNA-binding protein; Gene delivery; RNA; Chemistry; Computational biology; Biology; Nanotechnology; Gene; Cell; Genetic enhancement; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002377624,0.0002164128,0.0002557712,0.0001268607,0.0001250623,0.0002775907,0.0002272034,0.0003744922,0.0004826613],"category_scores_gemma":[0.0002142229,0.0001766771,0.0002752788,0.0001194999,0.0001911987,0.0001681707,0.0003078607,0.0003825967,0.0002394073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003038826,"about_ca_system_score_gemma":0.0002607355,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004553127,"about_ca_topic_score_gemma":0.0006750739,"domain_scores_codex":[0.999726,0.00003900389,0.00002409656,0.00006516367,0.0001043233,0.00004143655],"domain_scores_gemma":[0.9998808,0.00002094779,0.00003634769,0.00001969588,0.00002216502,0.0000200841],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009021654,0.000005457078,0.0000278752,0.00001878127,0.000002171584,0.00002306301,0.000009517058,0.0001412775,0.9983353,0.0001581594,0.0000435915,0.001225881],"study_design_scores_gemma":[0.000003574381,0.00002445581,0.0002472129,0.000001702448,0.000002144732,0.00005921685,0.000003167729,0.001789986,0.9962934,0.00003622609,0.001534491,0.000004541377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8749284,0.001557635,0.1158461,0.0002489075,0.0001179646,0.0001937263,0.0004264338,0.0008513842,0.005829535],"genre_scores_gemma":[0.9557433,0.0006606818,0.03940776,0.0001099186,0.00001324065,0.0001056927,0.0004411383,0.00009460653,0.003423547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004826613,"threshold_uncertainty_score":0.002204835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426294398317582,"score_gpt":0.2412428295681407,"score_spread":0.2269798855849649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}