{"id":"W3114055015","doi":"10.1002/anie.202014162","title":"Binding‐Mediated Formation of Ribonucleoprotein Corona for Efficient Delivery and Control of CRISPR/Cas9","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Government of Alberta","keywords":"Ribonucleoprotein; CRISPR; Cas9; HeLa; Corona (planetary geology); HEK 293 cells; Cell biology; RNA-binding protein; Gene delivery; RNA; Chemistry; Computational biology; Biology; Nanotechnology; Gene; Cell; Genetic enhancement; Biochemistry; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007644303,0.00008286806,0.000113857,0.00003749232,0.00002048297,0.000007873897,0.00009404648,0.00008055819,0.00002342815],"category_scores_gemma":[0.0001584234,0.00008283192,0.00006858679,0.00003552092,0.00005144925,0.00001252969,0.0000322433,0.00003441414,0.000002265524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001134427,"about_ca_system_score_gemma":0.00002159641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000990124,"about_ca_topic_score_gemma":0.000002783131,"domain_scores_codex":[0.9993917,0.00000874439,0.0002349847,0.0001530926,0.0001311423,0.00008035942],"domain_scores_gemma":[0.9993717,0.00002580247,0.0001810672,0.00006145708,0.0003184723,0.00004149175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004314267,0.00003799487,0.0002177335,0.00005890234,0.00004957999,3.615315e-7,0.00008736561,0.00005808298,0.996187,0.00002862885,0.00238252,0.0004603866],"study_design_scores_gemma":[0.001141818,0.0003455566,0.0003113867,0.00003393281,0.0000222351,0.000002869046,0.0001053652,0.002471589,0.9933369,0.00002503432,0.002124421,0.0000789202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9255835,0.00019264,0.07237044,0.0005539868,0.0001831012,0.0002248532,0.0006984429,0.000006549968,0.0001864397],"genre_scores_gemma":[0.9979522,0.0001178177,0.0001944533,0.0002618066,0.0002999926,0.00002825081,0.001118075,0.000007815942,0.0000195629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07236868,"threshold_uncertainty_score":0.3377788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426294398317582,"score_gpt":0.2412428295681407,"score_spread":0.2269798855849649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}