{"id":"W3114066113","doi":"10.2217/pgs-2020-0068","title":"Effect of <i>ABCG1</i> Gene DNA Methylations on the Lipid-Lowering Efficacy of Simvastatin","year":2020,"lang":"en","type":"article","venue":"Pharmacogenomics","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Natural Science Foundation of China","keywords":"Simvastatin; Triglyceride; ABCG1; Cholesterol; Chemistry; Methylation; Gene; Pharmacology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005099995,0.0001473102,0.0002725355,0.000153709,0.0001268398,0.0001708871,0.00008317895,0.0002025066,0.001146279],"category_scores_gemma":[0.0009082811,0.00007559465,0.0002578067,0.0001223138,0.0002158592,0.00007107672,0.0001339225,0.0002092968,0.0001013176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001266608,"about_ca_system_score_gemma":0.0001277736,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008775026,"about_ca_topic_score_gemma":0.0009261086,"domain_scores_codex":[0.9996612,0.0001756851,0.00001779832,0.00006427012,0.00004026834,0.00004079892],"domain_scores_gemma":[0.9995182,0.0002169113,0.0001112989,0.00004249815,0.00003923062,0.000071968],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01750835,0.0003169723,0.585282,0.00007600275,0.0005343926,0.0001452233,0.0001673338,0.001042445,0.3528881,0.0001166531,0.0001604288,0.04176208],"study_design_scores_gemma":[0.00008587139,0.00349742,0.9598313,0.00000499415,0.0002271607,0.0002598491,0.00005263836,0.001683591,0.03392179,0.00007307471,0.0003548648,0.000007490511],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995064,0.0001157685,0.0001531497,0.00002301773,0.000001414892,0.000003391187,0.00004805352,0.000004332961,0.0001444696],"genre_scores_gemma":[0.9996841,0.00002385147,0.0001480337,0.00001823759,0.00000180854,0.000002599715,0.00004344216,0.000001525984,0.0000764129],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001146279,"threshold_uncertainty_score":0.003834724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0322607238714876,"score_gpt":0.3105979934720819,"score_spread":0.2783372696005944,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}