{"id":"W3114125479","doi":"10.1016/j.neuroimage.2020.117676","title":"Time between milestone events in the Alzheimer's disease amyloid cascade","year":2020,"lang":"en","type":"article","venue":"NeuroImage","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Johnson and Johnson Pharmaceutical Research and Development; National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, San Diego; National Institutes of Health; Stiftelsen Bundy Academy; University Hospital Foundation; Genentech; Marcus och Amalia Wallenbergs minnesfond; Skånes universitetssjukhus; Magnus Bergvalls Stiftelse; Greta och Johan Kocks stiftelser; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Innogenetics; Region Skåne; Lund University Medical Faculty Foundation; Vetenskapsrådet; Eisai; Lunds Universitet; Northern California Institute for Research and Education; Servier; Knut och Alice Wallenbergs Stiftelse; Pfizer; Biogen; BioClinica; Synarc; Sveriges Läkarförbund; Roche; University of Southern California; IXICO; Takeda Pharmaceutical Company; Medpace; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Janssen Alzheimer Immunotherapy Research And Development; Hjärnfonden; Gyllenstiernska Krapperupsstiftelsen; F. Hoffmann-La Roche; Alzheimerfonden; Alzheimer's Drug Discovery Foundation; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Milestone; Cognition; Cohort; Pathological; Disease; Psychology; Cognitive reserve; Cognitive decline; Medicine; Alzheimer's disease; Internal medicine; Neuroscience; Amyloid (mycology); Dementia; Cognitive impairment; Pathology; Cartography; Geography","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00138076,0.0003636693,0.0002688361,0.000859185,0.0002092818,0.0004471453,0.0002970021,0.0004813608,0.001596115],"category_scores_gemma":[0.008085837,0.000190456,0.0003642076,0.0003560116,0.0001320105,0.0005079035,0.0004661284,0.0005262064,0.00025731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002623754,"about_ca_system_score_gemma":0.0002331285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003080085,"about_ca_topic_score_gemma":0.003091736,"domain_scores_codex":[0.9996957,0.00008460994,0.00002912122,0.0001044029,0.00004792147,0.00003831806],"domain_scores_gemma":[0.9962069,0.001288346,0.001725496,0.0001268055,0.0003420966,0.0003102954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001374069,0.00006128266,0.9906517,0.00003679901,0.0001627283,0.00009807193,0.00008828389,0.0006944927,0.0004206834,0.0001028581,0.0001443566,0.006164688],"study_design_scores_gemma":[0.00002323709,0.0004198939,0.9976625,0.0000118939,0.00006713816,0.0002264241,0.00004749114,0.0008479935,0.0002761151,0.0001058766,0.0003039779,0.000007383779],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973214,0.000700673,0.0006683748,0.0000288169,0.000006782314,0.0000226306,0.0008099666,0.00001284269,0.0004285095],"genre_scores_gemma":[0.997862,0.0001707387,0.0005869807,0.000008497459,0.00001076165,0.00003277073,0.0009072591,0.000002794505,0.000418201],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003080085,"threshold_uncertainty_score":0.007302225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04806730165237164,"score_gpt":0.3273494591956835,"score_spread":0.2792821575433119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}