{"id":"W3114126899","doi":"10.1371/journal.pone.0244183","title":"Ranibizumab treatment patterns in prior ranibizumab-treated neovascular age-related macular degeneration patients: Real-world outcomes from the LUMINOUS study","year":2020,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ottawa Fertility Centre; University of Ottawa","funders":"Novartis Pharma; Allergan; Alimera Sciences; Bayer HealthCare; Heidelberg Engineering; Genentech","keywords":"Ranibizumab; Medicine; Macular degeneration; Ophthalmology; Adverse effect; Visual acuity; Choroidal neovascularization; Prospective cohort study; Internal medicine; Bevacizumab; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001649372,0.0002854611,0.000613678,0.0004457828,0.0003145129,0.0005578346,0.0002843967,0.000362108,0.0007721794],"category_scores_gemma":[0.002342827,0.0002322502,0.0006197108,0.0005983454,0.000229187,0.0004556848,0.0004153005,0.0004128815,0.0002078875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004735265,"about_ca_system_score_gemma":0.0003664409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001712587,"about_ca_topic_score_gemma":0.00304083,"domain_scores_codex":[0.9988528,0.0004528972,0.0001684859,0.0002306114,0.0002175829,0.00007755472],"domain_scores_gemma":[0.9969168,0.0003153695,0.002205319,0.0001502043,0.000163289,0.0002490639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008658125,0.0006830279,0.9803076,0.00009815516,0.0004538279,0.0001135553,0.0001886868,0.00009830861,0.001419072,0.00001508748,0.0001783589,0.007786154],"study_design_scores_gemma":[0.0009723086,0.003863756,0.9927334,0.00002370475,0.0003067463,0.000677063,0.0001479603,0.000285555,0.0003987277,0.00001618956,0.000558654,0.00001601419],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991927,0.0003347806,0.00004666727,0.00001477562,0.000002021435,0.00003237811,0.0002062034,0.000002343108,0.0001682391],"genre_scores_gemma":[0.9989942,0.0001228113,0.0001467544,0.00004416699,0.00001061818,0.00002924457,0.0005709583,0.000001409592,0.00007982825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001712587,"threshold_uncertainty_score":0.008722782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05410665663594145,"score_gpt":0.2618273662184203,"score_spread":0.2077207095824788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}