{"id":"W3114136456","doi":"10.3390/v13010024","title":"Editing of the TRIM5 Gene Decreases the Permissiveness of Human T Lymphocytic Cells to HIV-1","year":2020,"lang":"en","type":"article","venue":"Viruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Fondation de l’UQTR","keywords":"Biology; Gene; Gene knockdown; clone (Java method); Allele; Effector; CRISPR; Molecular biology; HEK 293 cells; Virology; Genetics; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000127794,0.0001976944,0.0002220839,0.0001018852,0.0001053037,0.0003050361,0.0001856775,0.000239256,0.001869914],"category_scores_gemma":[0.0001506139,0.00007085806,0.0002092158,0.00006436728,0.000115534,0.00008227891,0.0001538046,0.0003972529,0.0004344108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001050236,"about_ca_system_score_gemma":0.0001108622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003806545,"about_ca_topic_score_gemma":0.0004854609,"domain_scores_codex":[0.9998397,0.00003105439,0.00001731839,0.00003705363,0.00003977261,0.00003509167],"domain_scores_gemma":[0.9998856,0.00003024299,0.00002481938,0.0000215767,0.00001192263,0.00002585056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004897474,0.00002093602,0.0001331173,0.00001707001,0.000004054722,0.00002553802,0.00001160818,0.00003198887,0.9987915,0.00001827827,0.0000273045,0.0008696572],"study_design_scores_gemma":[0.000007360148,0.0002689301,0.002325886,0.000003083896,0.0000148214,0.0001873014,0.00001636225,0.0004681386,0.9952667,0.000009973563,0.001428994,0.000002432414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970529,0.000602723,0.001226208,0.00004309379,0.00001352988,0.00001645571,0.0001591243,0.00006648818,0.0008195121],"genre_scores_gemma":[0.9963851,0.0002825712,0.001239456,0.00004499393,0.000006994066,0.00001470809,0.0003201799,0.00001702463,0.001688926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001869914,"threshold_uncertainty_score":0.006255507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04112523253066607,"score_gpt":0.288707723834249,"score_spread":0.247582491303583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}