{"id":"W3114238000","doi":"10.1161/circresaha.120.318409","title":"JNK2, a Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca <sup>2+</sup> ] <sub>SR</sub> Leak-Load Relationship","year":2020,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor; Calmodulin; Chemistry; SERCA; Internal medicine; Calcium; Ryanodine receptor 2; Endocrinology; Endoplasmic reticulum; Biophysics; ATPase; Biology; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001378204,0.0002710964,0.0004771806,0.0003269454,0.0006306283,0.0001082412,0.0001901277,0.0003647739,0.0005201798],"category_scores_gemma":[0.001817016,0.0002859416,0.0002409927,0.001354678,0.0002495094,0.0004633666,0.0001200762,0.00139915,0.002377739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005556282,"about_ca_system_score_gemma":0.0009468116,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007841615,"about_ca_topic_score_gemma":0.0000278597,"domain_scores_codex":[0.9954249,0.0007889985,0.0005387929,0.000907074,0.001515151,0.0008251235],"domain_scores_gemma":[0.9971917,0.0003807648,0.0001037821,0.0007192889,0.001013006,0.0005914599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002664978,0.0003964018,0.0271449,0.0005638812,0.0004568564,0.0007237197,0.007046939,0.08506668,0.8403264,0.001225824,0.01481236,0.01957099],"study_design_scores_gemma":[0.01136812,0.002006584,0.6038285,0.0004506877,0.0003842025,0.0006705082,0.00189251,0.2829335,0.08455553,0.006557251,0.0038552,0.001497389],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894604,0.0003818737,0.000976158,0.004209523,0.0001255265,0.001203142,0.00001579859,0.0001908832,0.00343666],"genre_scores_gemma":[0.996657,0.0001022109,0.00007468407,0.000593284,0.001485598,0.0001147361,0.0003201262,0.00006661677,0.0005857745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7557709,"threshold_uncertainty_score":0.9999593,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08093236664730623,"score_gpt":0.3573769601150417,"score_spread":0.2764445934677355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}