{"id":"W3114238000","doi":"10.1161/circresaha.120.318409","title":"JNK2, a Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca <sup>2+</sup> ] <sub>SR</sub> Leak-Load Relationship","year":2020,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Institutes of Health; Heart and Stroke Foundation of Canada","keywords":"Ryanodine receptor; Calmodulin; Chemistry; SERCA; Internal medicine; Calcium; Ryanodine receptor 2; Endocrinology; Endoplasmic reticulum; Biophysics; ATPase; Biology; Biochemistry; Medicine; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002005484,0.000584673,0.0002981068,0.0001950897,0.0002109007,0.0002650336,0.0003091151,0.0003240597,0.002863872],"category_scores_gemma":[0.0001692103,0.0001972367,0.0002828929,0.00009929996,0.0003259314,0.0002634718,0.0002991417,0.0005257807,0.0004605006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002997835,"about_ca_system_score_gemma":0.0002706907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002426445,"about_ca_topic_score_gemma":0.0005374454,"domain_scores_codex":[0.9998868,0.00001408795,0.000009881267,0.00003258016,0.00003304503,0.00002364962],"domain_scores_gemma":[0.999848,0.00001623823,0.00004129835,0.0000102959,0.00002101136,0.00006326562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002631558,0.00002860361,0.0001996725,0.00007480824,0.000004799743,0.00005716295,0.00001073533,0.00004042158,0.9982365,0.00009633952,0.00006380444,0.0009241215],"study_design_scores_gemma":[0.000120185,0.0006373628,0.01099073,0.00001760664,0.00006440553,0.0008202281,0.00004794509,0.001582667,0.979495,0.000159249,0.006050014,0.00001463508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875503,0.001799077,0.006298178,0.0002886544,0.0001232662,0.00006434415,0.0008171984,0.0001732484,0.00288571],"genre_scores_gemma":[0.987152,0.00119495,0.005046711,0.0002033922,0.00006885623,0.0001155727,0.0009219885,0.00008593684,0.005210515],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002863872,"threshold_uncertainty_score":0.009580672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08093236664730623,"score_gpt":0.3573769601150417,"score_spread":0.2764445934677355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}