{"id":"W3114295265","doi":"10.1021/acsomega.0c05254","title":"Systematic Design and Validation of Ion Channel Stabilization of Amphipathic α-Helical Peptides Incorporating Tryptophan Residues","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Chemistry; Tryptophan; Amphiphile; Peptide; Circular dichroism; Ion channel; Biophysics; Transmembrane protein; Helix (gastropod); Transmembrane domain; Liposome; Membrane; Stereochemistry; Biochemistry; Amino acid; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006118859,0.0003160254,0.0002579875,0.0001692997,0.0002264085,0.0002981972,0.0002698581,0.0003209806,0.0002074012],"category_scores_gemma":[0.0005964797,0.000143338,0.0002084478,0.0001989863,0.000294276,0.0002533063,0.0002453442,0.0004718117,0.0001191728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002521596,"about_ca_system_score_gemma":0.0003417255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000168686,"about_ca_topic_score_gemma":0.0002168856,"domain_scores_codex":[0.9997213,0.00007574294,0.00003914038,0.00005201683,0.00006777392,0.00004400512],"domain_scores_gemma":[0.9995252,0.00008463432,0.00014896,0.00005434707,0.0001178256,0.00006904326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007908155,0.00009002133,0.0001608426,0.00005852914,0.000006128114,0.00004311168,0.00002199037,0.0007623549,0.9968742,0.0001219634,0.00001327155,0.001768515],"study_design_scores_gemma":[0.00002487903,0.0006908111,0.0004161808,0.00000564148,0.00001310132,0.00005648012,0.00001418176,0.001241757,0.9967678,0.00002697922,0.0007364419,0.000005850266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933922,0.0005599048,0.005277724,0.0000411229,0.00001416667,0.0001728481,0.00008861723,0.00002297472,0.0004303332],"genre_scores_gemma":[0.9806281,0.0008009872,0.01774303,0.00004556857,0.00001024688,0.0001305882,0.0002007535,0.00002075772,0.0004199455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006118859,"threshold_uncertainty_score":0.003235996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02948461144319468,"score_gpt":0.2346938165802104,"score_spread":0.2052092051370157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}