{"id":"W3114295265","doi":"10.1021/acsomega.0c05254","title":"Systematic Design and Validation of Ion Channel Stabilization of Amphipathic α-Helical Peptides Incorporating Tryptophan Residues","year":2020,"lang":"en","type":"article","venue":"ACS Omega","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University","funders":"Ministry of Education, Culture, Sports, Science and Technology","keywords":"Chemistry; Tryptophan; Amphiphile; Peptide; Circular dichroism; Ion channel; Biophysics; Transmembrane protein; Helix (gastropod); Transmembrane domain; Liposome; Membrane; Stereochemistry; Biochemistry; Amino acid; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003241056,0.0001129995,0.000380058,0.00006224899,0.00007397601,0.00001104619,0.00008573227,0.0001321762,0.000004778782],"category_scores_gemma":[0.0003825499,0.00009774323,0.00003973801,0.0001365111,0.000180443,0.0001644568,0.00005514875,0.00009384003,0.000006688483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009064394,"about_ca_system_score_gemma":0.00003006938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000320516,"about_ca_topic_score_gemma":0.000002230596,"domain_scores_codex":[0.998937,0.0003114811,0.000432945,0.0001675041,0.00003919825,0.0001119324],"domain_scores_gemma":[0.9991287,0.0002689773,0.0003799215,0.0001069909,0.00009958779,0.00001581686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001011019,0.00003744368,0.0005124543,0.003491036,0.00005655909,4.831928e-7,0.002066194,0.000242565,0.99233,0.001021278,0.00008946731,0.00005137652],"study_design_scores_gemma":[0.0003911213,0.0003318122,0.0004019575,0.0009576319,0.00005354012,0.000007295971,0.001388119,0.0001323905,0.995656,0.0005743471,0.000002846058,0.0001029865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884889,0.0007297316,0.01009519,0.0001719491,0.00006495244,0.0003757905,0.00001331824,0.0000307599,0.00002941393],"genre_scores_gemma":[0.9992692,0.00005936406,0.0005084219,0.00004831776,0.0000243494,0.00001003832,0.00003892033,0.00001178647,0.00002960863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0107803,"threshold_uncertainty_score":0.3985853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02948461144319468,"score_gpt":0.2346938165802104,"score_spread":0.2052092051370157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}