{"id":"W3114444897","doi":"10.3390/molecules26010115","title":"Synthesis of Galectin Inhibitors by Regioselective 3′-O-Sulfation of Vanillin Lactosides Obtained under Phase Transfer Catalysis","year":2020,"lang":"en","type":"article","venue":"Molecules","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Université du Québec à Montréal","funders":"McGill University Health Centre; Université du Québec à Montréal; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Chemistry; Vanillin; Regioselectivity; Moiety; Aldehyde; Catalysis; Organic chemistry; Bromide; Residue (chemistry); Knoevenagel condensation; Phase-transfer catalyst; Isoeugenol; Transesterification; Chemoselectivity; Medicinal chemistry; Combinatorial chemistry; Eugenol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009235747,0.0001673825,0.0004126334,0.00008225202,0.00005874844,0.000003409063,0.0001406711,0.0002112486,0.000175311],"category_scores_gemma":[0.0001510469,0.0001505577,0.0001490073,0.0003366222,0.0002085349,0.00003866001,0.00001970574,0.0001455039,0.0000115248],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002656959,"about_ca_system_score_gemma":0.00006069857,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000271159,"about_ca_topic_score_gemma":0.00006288847,"domain_scores_codex":[0.9988653,0.0002189134,0.0003704098,0.0002977193,0.0000399556,0.0002076857],"domain_scores_gemma":[0.9994226,0.0001629689,0.0001277337,0.0001398553,0.000121045,0.00002577593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004565556,0.0002012164,0.0004421149,0.00003697548,0.0003341619,7.695318e-7,0.0007343147,0.00002561539,0.9921373,0.0003572182,0.001508167,0.003765555],"study_design_scores_gemma":[0.001037592,0.000588458,0.0004647857,0.00001912215,0.0001384098,0.000003986157,0.0004993219,0.00001153635,0.9961799,0.0001137094,0.0008017198,0.000141432],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863051,0.001973063,0.009959519,0.0007669582,0.00007798957,0.0001871167,0.0001163334,0.0000397272,0.0005741988],"genre_scores_gemma":[0.9994416,0.00009741998,0.00004946368,0.0001716058,0.0000156101,0.00002618977,0.0001091479,0.00001800931,0.00007090378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01313656,"threshold_uncertainty_score":0.6139564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0113216999877794,"score_gpt":0.2321758922713873,"score_spread":0.2208541922836079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}