{"id":"W3114455891","doi":"10.1016/j.virol.2020.12.010","title":"Programmed −1 Ribosomal Frameshifting in coronaviruses: A therapeutic target","year":2020,"lang":"en","type":"article","venue":"Virology","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Defense Threat Reduction Agency; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of Maryland","keywords":"Translational frameshift; Biology; Mechanism (biology); Frameshift mutation; Virology; Coronavirus; Computational biology; Population; Coronavirus disease 2019 (COVID-19); Genetics; Mutation; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002569807,0.0003419713,0.0002508192,0.0002333709,0.0002088262,0.0005071162,0.0002810961,0.0005393912,0.001557875],"category_scores_gemma":[0.0001429556,0.0001046571,0.0002090989,0.000123013,0.0002484657,0.0002838319,0.0001438048,0.001089916,0.000377515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003671449,"about_ca_system_score_gemma":0.0002516384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000128899,"about_ca_topic_score_gemma":0.0001601799,"domain_scores_codex":[0.9999268,0.00002019505,0.000003899128,0.00001172695,0.00001769774,0.00001964021],"domain_scores_gemma":[0.9999465,0.00001529976,0.00001157375,0.000006156892,0.000008677561,0.00001183262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001756937,0.0004366481,0.0005669963,0.0003737549,0.0000254871,0.0005363306,0.00007005227,0.0008065071,0.865906,0.01400221,0.00214195,0.113377],"study_design_scores_gemma":[0.0003809969,0.006118132,0.002862078,0.0001591479,0.00009299413,0.003395975,0.0001067323,0.002780034,0.8850618,0.009616227,0.08939026,0.00003568314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6471893,0.2663628,0.03406141,0.01039076,0.002945361,0.0002804329,0.0003783547,0.0006597704,0.03773187],"genre_scores_gemma":[0.9475924,0.03382304,0.00539564,0.000893267,0.0006053943,0.00009112592,0.0002225828,0.00003940978,0.01133713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557875,"threshold_uncertainty_score":0.005211651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02385805337730814,"score_gpt":0.255896140275581,"score_spread":0.2320380868982728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}