{"id":"W3114502674","doi":"10.1039/d0nh00605j","title":"Targeted liposomal drug delivery: a nanoscience and biophysical perspective","year":2020,"lang":"en","type":"review","venue":"Nanoscale Horizons","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":289,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Waterloo; National Institute for Nanotechnology; University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Liposome; PEGylation; Drug delivery; Nanotechnology; Targeted drug delivery; Aptamer; PLGA; Chemistry; Doxorubicin; Controlled release; Biophysics; Materials science; Nanoparticle; Medicine; Biochemistry; Biology; Polyethylene glycol; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003491345,0.0008538687,0.002103402,0.0002471982,0.0004388092,0.0003134286,0.001007393,0.0003541322,0.0001801137],"category_scores_gemma":[0.0003147336,0.0007253471,0.0005191996,0.001320746,0.0008617404,0.0004344667,0.0007268747,0.0006397018,0.001719533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005036493,"about_ca_system_score_gemma":0.001194051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002497597,"about_ca_topic_score_gemma":0.00003391209,"domain_scores_codex":[0.9950164,0.0005416542,0.0007649742,0.001817029,0.000806955,0.001052985],"domain_scores_gemma":[0.9974269,0.0004847831,0.0004136977,0.0007296061,0.0002252453,0.0007197215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001579399,0.001120981,0.00001008733,0.006344281,0.0002262461,0.001050944,0.001805689,0.000001601023,0.3651257,0.007416551,0.01246343,0.6042766],"study_design_scores_gemma":[0.0005223532,0.0005437664,0.000004266765,0.002588559,0.001047736,0.0001194016,0.0002716196,0.0000854989,0.02199776,0.0002258267,0.9711677,0.001425478],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0108948,0.9851375,0.0000287707,0.0003267361,0.001125777,0.00113166,0.0006694167,0.0004050712,0.000280294],"genre_scores_gemma":[0.00510521,0.9924458,0.001039771,0.0001062211,0.0006440165,0.0002139098,0.00002925624,0.0001268666,0.0002889689],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9587043,"threshold_uncertainty_score":0.9995198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01694266750914215,"score_gpt":0.2695564807051118,"score_spread":0.2526138131959696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}