{"id":"W3114559674","doi":"10.21203/rs.3.rs-121995/v1","title":"Mast Cells-derived Exosomes Promote the Development of Experimental Cerebral Malaria","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Guangdong Pharmaceutical University; National Natural Science Foundation of China","keywords":"Plasmodium berghei; Microvesicles; Degranulation; Pathogenesis; CD63; In vivo; Exosome; Cell biology; Immunology; Ex vivo; Biology; Medicine; Pathology; Receptor; Malaria; Internal medicine; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00029268,0.0005611227,0.0003981988,0.0003279834,0.000179882,0.0002913634,0.0001509576,0.0004359955,0.001658949],"category_scores_gemma":[0.0002871148,0.0001651552,0.0003394505,0.000113906,0.0002955905,0.000404738,0.0003154336,0.001247498,0.0003175336],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002071158,"about_ca_system_score_gemma":0.0002114992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001486011,"about_ca_topic_score_gemma":0.0002142278,"domain_scores_codex":[0.9997717,0.00003958993,0.00002214855,0.0000424529,0.00005162654,0.00007253639],"domain_scores_gemma":[0.9997646,0.00002551918,0.00008079679,0.00002279421,0.00002604268,0.00008011985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002244315,0.0005806759,0.001413397,0.0002351747,0.00002665344,0.0005431301,0.00008744137,0.00009401009,0.9902929,0.0002532003,0.0003690624,0.003859933],"study_design_scores_gemma":[0.0002520486,0.004641105,0.02244869,0.00005978805,0.0001005449,0.001079501,0.0001928345,0.002207301,0.964608,0.0003091777,0.004085396,0.00001561358],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936103,0.001828882,0.002341201,0.0002412803,0.0001704487,0.0001144197,0.0004043193,0.000110649,0.001178468],"genre_scores_gemma":[0.9957368,0.00091237,0.001011238,0.0000874114,0.0000567647,0.0001192309,0.000321027,0.00001159913,0.001743466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001658949,"threshold_uncertainty_score":0.005549729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05483572400803,"score_gpt":0.3590349662660717,"score_spread":0.3041992422580417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}