{"id":"W3114706432","doi":"10.1016/j.omtn.2020.12.022","title":"Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Promoter; Human immunodeficiency virus (HIV); Biology; Genetics; Computational biology; Virology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005574947,0.0001834694,0.0002830205,0.0003380884,0.000148373,0.000347504,0.0001396312,0.00025916,0.0005993985],"category_scores_gemma":[0.0004191497,0.0001492478,0.0003096413,0.0002469137,0.0002605432,0.0002136381,0.0001318637,0.0005417193,0.0003044228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002831587,"about_ca_system_score_gemma":0.0002005329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008773863,"about_ca_topic_score_gemma":0.0006926397,"domain_scores_codex":[0.9995382,0.0001012207,0.00006976495,0.00008314388,0.0001350451,0.00007267446],"domain_scores_gemma":[0.9993429,0.0002562598,0.00009730308,0.00007029068,0.0001546841,0.00007855548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001644439,0.00005521782,0.0004533181,0.00002839116,0.000005935132,0.00001009228,0.00004678068,0.0001426908,0.9972887,0.00005647866,0.00004582592,0.00170211],"study_design_scores_gemma":[0.000005168116,0.0004945473,0.002358446,0.000003347499,0.00001093023,0.00002037471,0.00001945452,0.001092986,0.9955903,0.00001492653,0.0003851981,0.000004304151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943242,0.001413759,0.002607806,0.00004070421,0.00002036252,0.000019884,0.000487889,0.00004534201,0.001040061],"genre_scores_gemma":[0.9909226,0.00115403,0.003623237,0.00006432497,0.00001955312,0.00004989033,0.001659164,0.00004313351,0.002464064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008773863,"threshold_uncertainty_score":0.002948344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196704284237798,"score_gpt":0.2769143256621299,"score_spread":0.2549472828197519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}