{"id":"W3114706432","doi":"10.1016/j.omtn.2020.12.022","title":"Efficacy, accumulation, and transcriptional profile of anti-HIV shRNAs expressed from human U6, 7SK, and H1 promoters","year":2020,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Promoter; Human immunodeficiency virus (HIV); Biology; Genetics; Computational biology; Virology; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007658248,0.0002071926,0.0002488387,0.00003607959,0.000088523,0.00003067846,0.0001352438,0.0001586458,0.00001181571],"category_scores_gemma":[0.00002072468,0.0001871228,0.0001015081,0.0000948835,0.0001699084,0.000008894031,0.00005598072,0.00009011701,7.266906e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004336047,"about_ca_system_score_gemma":0.00001590664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001196725,"about_ca_topic_score_gemma":0.000001056844,"domain_scores_codex":[0.9988768,0.00007769509,0.0002573014,0.0004711253,0.0001602777,0.0001567631],"domain_scores_gemma":[0.9994707,0.000006618363,0.0001104759,0.0002451906,0.00007002771,0.00009702383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001496723,0.00006318804,0.001867129,0.00001033662,0.0001342725,0.000003488434,0.0001737534,0.00001027426,0.9949718,0.00005604638,0.00008275638,0.002477251],"study_design_scores_gemma":[0.001194777,0.0003184389,0.01514965,0.0000166502,0.00003757358,0.000002697409,0.00003572906,0.0002132608,0.9793987,0.0001591054,0.003245669,0.0002277052],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908162,0.0008476187,0.007266319,0.0006185949,0.00001106995,0.0002585129,0.00008539454,0.00004284354,0.00005342514],"genre_scores_gemma":[0.9917654,0.0002769193,0.006870348,0.0005905255,0.00006668035,0.000005929809,0.00037511,0.00003235414,0.00001672882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01557309,"threshold_uncertainty_score":0.7630646,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196704284237798,"score_gpt":0.2769143256621299,"score_spread":0.2549472828197519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}