{"id":"W3114847923","doi":"10.1186/s13223-021-00543-4","title":"Interleukin-35 inhibited the production of histamine and pro-inflammatory cytokines through suppression MAPKs pathway in HMC-1 cells","year":2021,"lang":"en","type":"article","venue":"Allergy Asthma and Clinical Immunology","topic":"Urticaria and Related Conditions","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health and Family Planning Commission of Sichuan Province","keywords":"Histamine; Cytokine; Pathogenesis; Phosphorylation; Mast cell; p38 mitogen-activated protein kinases; Molecular biology; Immune system; Interleukin; Immunology; Chemistry; Cell biology; Biology; Endocrinology; MAPK/ERK pathway","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046798,0.0001333953,0.0003698394,0.0000557721,0.00007122566,0.000007667032,0.00005739869,0.0003364433,0.0001158921],"category_scores_gemma":[0.000327275,0.00008772562,0.00008073472,0.0001610959,0.0006359519,0.00007397959,0.0001363935,0.0005514105,0.000005285642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000153542,"about_ca_system_score_gemma":0.0001031094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003094714,"about_ca_topic_score_gemma":0.00009651578,"domain_scores_codex":[0.9984748,0.0002495352,0.0006585278,0.0003445213,0.00008722652,0.0001853592],"domain_scores_gemma":[0.9990772,0.0002973269,0.0001442928,0.0003135467,0.0001259878,0.00004164426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001293348,0.001314994,0.009157748,0.00007662425,0.001757849,0.0003762171,0.001912426,0.000004696099,0.9566002,0.006077494,0.001246689,0.02018164],"study_design_scores_gemma":[0.009207863,0.002744046,0.4751616,0.001473656,0.0003721013,0.001360229,0.003655888,0.0002183045,0.3854646,0.003038485,0.1167948,0.0005083749],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898838,0.003248408,0.00001927354,0.005463789,0.0007185569,0.0002189232,0.000003364304,0.0000229591,0.0004208698],"genre_scores_gemma":[0.9931054,0.005031888,0.0001551503,0.0002216476,0.0001079819,0.00002046802,0.00004224471,0.00001414792,0.001301105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5711356,"threshold_uncertainty_score":0.3577347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01693113167865817,"score_gpt":0.2813032224866444,"score_spread":0.2643720908079862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}