{"id":"W3114933038","doi":"10.1161/circresaha.120.318429","title":"Ca 2+ -CaM Dependent Inactivation of RyR2 Underlies Ca 2+ Alternans in Intact Heart","year":2020,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"Canadian Institutes of Health Research; Generalitat de Catalunya; Heart and Stroke Foundation of Canada; Government of Canada","keywords":"Ryanodine receptor 2; Ryanodine receptor; Ventricle; Endoplasmic reticulum; Myocyte; Calmodulin; Internal medicine; Calcium; Endocrinology; Wild type; Chemistry; Mutant; Biology; Cell biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002725698,0.0004013739,0.0003423101,0.0001673577,0.0001328484,0.0002655417,0.0004543541,0.0004624969,0.00122919],"category_scores_gemma":[0.0002425849,0.0002009651,0.0002653899,0.00007287768,0.0007842727,0.000306321,0.0002952371,0.0007492554,0.0003006424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000269331,"about_ca_system_score_gemma":0.0001628011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002805186,"about_ca_topic_score_gemma":0.0003637366,"domain_scores_codex":[0.9998846,0.00001411953,0.00001897879,0.00002852841,0.00003130034,0.00002238994],"domain_scores_gemma":[0.9997471,0.00004671156,0.000117151,0.00002838113,0.00001635039,0.00004435838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005937642,0.000007181967,0.000215823,0.00001944687,0.000001995827,0.00009197996,0.000005971187,0.00002211179,0.9993114,0.0000429696,0.00001322975,0.0002084751],"study_design_scores_gemma":[0.00006331764,0.0003577497,0.02322989,0.00001424016,0.00003152374,0.001291775,0.00003454897,0.002097348,0.9718226,0.000207525,0.0008407233,0.000008702537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944951,0.0007654707,0.003572893,0.0001818813,0.00002539022,0.00003788515,0.0001643706,0.00008712631,0.0006699419],"genre_scores_gemma":[0.9972751,0.0003127037,0.001503964,0.00006786557,0.00001470111,0.00004035908,0.0001291259,0.00001746729,0.0006386599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00122919,"threshold_uncertainty_score":0.004112065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06508350175407962,"score_gpt":0.3554596021296571,"score_spread":0.2903761003755775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}