{"id":"W3114933038","doi":"10.1161/circresaha.120.318429","title":"Ca 2+ -CaM Dependent Inactivation of RyR2 Underlies Ca 2+ Alternans in Intact Heart","year":2020,"lang":"en","type":"article","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta","funders":"Canadian Institutes of Health Research; Generalitat de Catalunya; Heart and Stroke Foundation of Canada; Government of Canada","keywords":"Ryanodine receptor 2; Ryanodine receptor; Ventricle; Endoplasmic reticulum; Myocyte; Calmodulin; Internal medicine; Calcium; Endocrinology; Wild type; Chemistry; Mutant; Biology; Cell biology; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007416161,0.0001938728,0.0005122594,0.0004554842,0.0001572551,0.00003041625,0.0001343998,0.0002362002,0.0003782849],"category_scores_gemma":[0.0007066592,0.0001923257,0.0001657031,0.0009587026,0.0001873947,0.0002429877,0.0001067036,0.0009828149,0.0002180406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003854591,"about_ca_system_score_gemma":0.000433324,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009800871,"about_ca_topic_score_gemma":0.00002869194,"domain_scores_codex":[0.9970142,0.0005267191,0.0005049417,0.0005256388,0.0008801981,0.0005483128],"domain_scores_gemma":[0.998504,0.0004018079,0.00008133942,0.0003999315,0.0003943846,0.0002185826],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002185176,0.0005165478,0.1254169,0.0008466995,0.000358222,0.0002951651,0.01518844,0.7514219,0.08992931,0.001539261,0.005913586,0.006388813],"study_design_scores_gemma":[0.0047897,0.001439857,0.3512557,0.0003834731,0.00007981287,0.0001857075,0.005780056,0.6143532,0.01778668,0.001743725,0.001687082,0.0005149795],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895459,0.0002093883,0.0004993993,0.007624763,0.00003173918,0.0008083457,0.00001679792,0.00004264321,0.00122102],"genre_scores_gemma":[0.99843,0.00008272022,0.00008004434,0.0005624706,0.0004346172,0.00006160023,0.0001683081,0.00003486036,0.0001453601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2258388,"threshold_uncertainty_score":0.7842814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06508350175407962,"score_gpt":0.3554596021296571,"score_spread":0.2903761003755775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}